Tissue selectivity

Tissue selectivity is a topic in distribution (pharmacology) and property of some drugs. It refers to when a drug occurs in disproportionate concentrations and/or has disproportionate effects in specific tissues relative to other tissues.[1] An example of such drugs are selective estrogen receptor modulators (SERM) like tamoxifen, which show estrogenic effects in some tissues and antiestrogenic effects in other tissues. Another example is peripherally-selective drugs, which do not cross the blood-brain-barrier into the central nervous system and hence are tissue-selective for the periphery.

References

  1. ↑ Zweten (5 September 1997). Antihypertensive Drugs. CRC Press. p. 345. ISBN 9789057021220. The term “tissue selectivity” is used for an agent showing varying degrees of potency between tissues, with a preferential action in a given one.


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