Tissue factor pathway inhibitor

TFPI
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTFPI, EPI, LACI, TFI, TFPI1, tissue factor pathway inhibitor
External IDsOMIM: 152310 MGI: 1095418 HomoloGene: 4579 GeneCards: TFPI
Orthologs
SpeciesHumanMouse
Entrez

7035

21788

Ensembl

ENSG00000003436

ENSMUSG00000027082

UniProt

P10646

O54819

RefSeq (mRNA)

NM_001177319
NM_001177320
NM_011576
NM_001355271
NM_001355273

RefSeq (protein)

NP_001170790
NP_001170791
NP_035706
NP_001342200
NP_001342202

Location (UCSC)Chr 2: 187.46 – 187.57 MbChr 2: 84.43 – 84.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM.

Genetics

The gene for TFPI is located on chromosome 2q31-q32.1, and has nine exons which span 70 kb. A similar gene, termed TFPI2, has been identified on chromosome 7, at locus 7q21.3; in addition to TFPI activity, its product also has retinal pigment epithelial cell growth-promoting properties.

Protein structure

TFPI has a relative molecular mass of 34,000 to 40,000 depending on the degree of proteolysis of the C-terminal region.

TFPI consists of a highly negatively charged amino-terminus, three tandemly linked Kunitz domains, and a highly positively charged carboxy-terminus. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypsin inhibitor and bovine basic pancreatic trypsin inhibitor.

Interactions

Tissue factor pathway inhibitor has been shown to interact with Factor X.[5]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000003436 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027082 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Broze, G J; Warren L A; Novotny W F; Higuchi D A; Girard J J; Miletich J P (Feb 1988). "The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action". Blood. UNITED STATES. 71 (2): 335–43. doi:10.1182/blood.V71.2.335.335. ISSN 0006-4971. PMID 3422166.

Further reading

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