Triazolopyridine

Chemical structures of selected examples of triazolopyridine isomers and their IUPAC names

Triazolopyridines are a class of heterocyclic chemical compounds with a triazole ring fused to a pyridine ring. There are multiple isomers which differ by the location of the nitrogen atoms and the nature of the ring fusion.

The term triazolopyridine can also refer to a class of antidepressant drugs whose chemical structure includes a trazolopyridine-derived ring system.[1] One example is trazodone.[2]

Other pharmaceutical drugs that contain a triazolopyridine ring system include filgotinib, tucatinib, and enarodustat. In addition, the reagents used in organic chemistry HATU, HOAt, and PyAOP[3] are triazolopyridine derivatives.

References

  1. ↑ "Triazolopyridine antidepressant". dictionary.com.
  2. ↑ J P Feighner (1980). "Trazodone, a triazolopyridine derivative, in primary depressive disorder". J Clin Psychiatry. 41 (7): 250–255. PMID 6993447.
  3. ↑ Jacques Coste, Patrick Jouin (April 15, 2003). "(7-Azabenzotriazol-1-yloxy)tris(pyrrolidino)phosphonium Hexafluorophosphate". Encyclopedia of Reagents for Organic Synthesis. doi:10.1002/047084289X.rn00199.
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