Trichoepithelioma

Trichoepithelioma
Other names: Brooke's tumour Epithelioma afenoides cysticum .
Trichoepithelioma
SpecialtyDermatology
Usual onsetusually young adults
Diagnostic methodClinical history and examination are important. In a significant number of patients there is a familial trait. Examination will white, translucent, slightly raised papules which have a pearly white appearance.
TreatmentAny suspicicion of malignant change calls for adequate excision and histological examination . The only other reason for treatment is cosmetic . Partial destruction is usually followed by regrowth . Many treatment modalities may be used including surgical excision , curettage , cryotherapy and dermabrasion . High energy pulsed carbon dioxide laser has also been advocated as a useful treatment .

Trichoepithelioma is a neoplasm of the adnexa of the skin.[1] Its appearance is similar to basal cell carcinoma.[2]

Types

Trichoepitheliomas may be divided into the following types:[3]: 672 

Pathology

Trichoepitheliomas consisted of nests of basaloid cells. They lack the myxoid stroma and artefactual clefting seen in basal cell carcinoma. Mitoses are uncommon when compared to basal cell carcinoma.

One form has been mapped to chromosome 9p21.[4]

Images

  • Trichoepithelioma (demoscopy)
    Trichoepithelioma (demoscopy)
  • Micrograph of a trichoepithelioma. H&E stain.
    Micrograph of a trichoepithelioma. H&E stain.
  • Trichoepithelioma-pathology
    Trichoepithelioma-pathology

See also

References

  1. ↑ "Trichoepithelioma: Overview - eMedicine Dermatology". Archived from the original on 2017-09-22. Retrieved 2009-02-11.
  2. ↑ DE, Elder; D, Massi; RA, Scolyer; R, Willemze (2018). "1. Keratinocynic/epidermal tomours: Basal cell carcinoma". WHO Classification of Skin Tumours. Vol. 11 (4th ed.). Lyon (France): World Health Organization. pp. 26–34. ISBN 978-92-832-2440-2. Archived from the original on 2022-07-11. Retrieved 2022-08-08.
  3. ↑ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
  4. ↑ Salhi A, Bornholdt D, Oeffner F, et al. (August 2004). "Multiple familial trichoepithelioma caused by mutations in the cylindromatosis tumor suppressor gene". Cancer Res. 64 (15): 5113–7. doi:10.1158/0008-5472.CAN-04-0307. PMID 15289313. Archived from the original on 2013-02-23. Retrieved 2020-12-14.
Classification
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