Zinc sulfate (medical use)

Zinc sulfate
Chemical model
Names
Pronunciationzink SUL fate
Trade namesSolvazinc, Micro-Zn, others
IUPAC name
  • Zinc sulfate
Clinical data
WHO AWaReUnlinkedWikibase error: ⧼unlinkedwikibase-error-statements-entity-not-set⧽
Pregnancy
category
  • US: C (Risk not ruled out)[1]
    Routes of
    use    		By mouth, intravenous
    Defined daily dose0.6 gram (by mouth)[2]
    External links
    AHFS/Drugs.comProfessional Drug Facts
    Legal
    License data
    Legal status
    Chemical and physical data
    FormulaO4SZn
    Molar mass161.47 g·mol−1
    3D model (JSmol)
    SMILES
    • [O-]S(=O)(=O)[O-].[Zn+2]
    InChI
    • InChI=1S/H2O4S.Zn/c1-5(2,3)4;/h(H2,1,2,3,4);/q;+2/p-2
    • Key:NWONKYPBYAMBJT-UHFFFAOYSA-L

    Zinc sulfate is used medically as a dietary supplement.[3] Specifically it is used to treat zinc deficiency and to prevention the conditions in those at high risk.[3] This includes use together with oral rehydration therapy for children who have diarrhea.[4] General use is not recommended.[3] It may be taken by mouth or by injection into a vein.[3]

    Side effects may include abdominal pain, vomiting, headache, and feeling tired.[4] While normal doses are deemed safe in pregnancy and breastfeeding, the safety of larger doses is unclear.[1] Greater care should be taken in those with kidney problems.[4] Zinc is an essential mineral in people as well as other animals.[5]

    The medical use of zinc sulfate began as early as the 1600s.[6] It is on the World Health Organization's List of Essential Medicines.[7] Zinc sulfate is available as a generic medication and over the counter.[3][1] The wholesale cost in the developing world is about US$0.01–18 per day.[8] In the United Kingdom ten days of treatment costs the NHS about 4.32 pounds.[3]

    Medical uses

    The use of zinc sulfate supplements together with oral rehydration therapy decreases the number of bowel movements and the time until the diarrhea stops.[4] Its use in this situation is recommended by the World Health Organization.[4]

    Zinc sulfate is also an important part of parenteral nutrition.[3]

    Dosage

    The defined daily dose is 0.6 gram (by mouth).[2] For children 6 month to 5 years old the recommended dose is 20 mg once per day for 10 days while in those under 6 month half this amount is recommended.[9]

    Society and culture

    Cost

    The wholesale cost in the developing world is about US$0.01–18 per day.[8] In the United Kingdom ten days of treatment costs the NHS about 4.32 pounds.[3]

    • Zinc costs (US)
      Zinc costs (US)
    • Zinc prescriptions (US)
      Zinc prescriptions (US)

    References

    1. 1 2 3 "Zinc sulfate Use During Pregnancy". Drugs.com. 9 December 2019. Archived from the original on 16 September 2016. Retrieved 8 June 2020.
    2. 1 2 "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 29 October 2020. Retrieved 12 September 2020.
    3. 1 2 3 4 5 6 7 8 British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 700. ISBN 9780857111562.
    4. 1 2 3 4 5 World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 349–51. hdl:10665/44053. ISBN 9789241547659.
    5. ↑ Council, National Research; Studies, Division on Earth and Life; Resources, Board on Agriculture and Natural; Animals, Committee on Minerals and Toxic Substances in Diets and Water for (2006). Mineral Tolerance of Animals: Second Revised Edition, 2005. National Academies Press. p. 420. ISBN 9780309096546. Archived from the original on 2017-01-16.
    6. ↑ Sneader, Walter (2005). Drug Discovery: A History. John Wiley & Sons. p. 62. ISBN 9780471899792. Archived from the original on 2017-01-16.
    7. ↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
    8. 1 2 "Zinc Sulfate". International Drug Price Indicator Guide. Archived from the original on 22 January 2018. Retrieved 8 December 2016.
    9. ↑ "ZINC SULFATE oral - Essential drugs". medicalguidelines.msf.org. Archived from the original on 27 August 2021. Retrieved 25 August 2020.
    • "Zinc Sulfate". Drug Information Portal. U.S. National Library of Medicine. Archived from the original on 2020-07-14. Retrieved 2020-07-14.
    Identifiers:
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