Paroxetine

Paroxetine
Names
Trade namesPaxil, Seroxat, others
IUPAC name
  • (3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine
Clinical data
Drug classSelective serotonin reuptake inhibitor (SSRI)[1]
Main usesMajor depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, posttraumatic stress disorder, generalized anxiety disorder, premenstrual dysphoric disorder[1]
Side effectsDrowsiness, dry mouth, loss of appetite, sweating, trouble sleeping, sexual dysfunction[1]
Pregnancy
category
  • AU: D
  • US: D (Evidence of risk)
    Routes of
    use    		By mouth
    Defined daily dose20 mg[2]
    External links
    AHFS/Drugs.comMonograph
    US NLMParoxetine
    MedlinePlusa698032
    Legal
    License data
    Legal status
    • AU: S4 (Prescription only)
    • CA: ℞-only
    • UK: POM (Prescription only)
    • US: ℞-only
    • In general: ℞ (Prescription only)
    Pharmacokinetics
    BioavailabilityExtensively absorbed from the GI tract, but extensive first-pass metabolism in the liver[3][4][5][6]
    Protein binding93–95%[3][4][5]
    MetabolismExtensive, hepatic (mostly CYP2D6-mediated)[3][4][5]
    Elimination half-life21 hours[3][4][5]
    ExcretionKidney (64%; 2% unchanged and 62% as metabolites), faecal (36%; <1% unchanged)[3][4][5]
    Chemical and physical data
    FormulaC19H20FNO3
    Molar mass329.3 g/mol
    3D model (JSmol)
    SMILES
    • c1cc(ccc1[C@@H]2CCNC[C@H]2COc3ccc4c(c3)OCO4)F
    InChI
    • InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1 checkY
    • Key:AHOUBRCZNHFOSL-YOEHRIQHSA-N checkY

    Paroxetine, sold under the brand names Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.[1] It is used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder.[1] It has also been used in the treatment of premature ejaculation and hot flashes due to menopause.[1][7] It is taken by mouth.[1]

    Common side effects include drowsiness, dry mouth, loss of appetite, sweating, trouble sleeping, and sexual dysfunction.[1] Serious side effects may include suicide in those under the age of 25, serotonin syndrome, and mania.[1] While the rate of side effects appears similar compared to other SSRIs and SNRIs, antidepressant discontinuation syndromes may occur more often.[8][9] Use in pregnancy is not recommended while use during breastfeeding is relatively safe.[10] It is believed to work by blocking the re-uptake of the chemical serotonin by neurons in the brain.[1]

    Paroxetine was approved for medical use in the United States in 1992 and initially sold by GlaxoSmithKline.[1][11] It is available as a generic medication.[12] A month supply in the United Kingdom costs the NHS about £1.10 per month as of 2019.[12] In the United States the wholesale cost of this amount is about US$2.40.[13] In 2017, it was the 68th most commonly prescribed medication in the United States, with more than eleven million prescriptions.[14][15] The United States Department of Justice fined GlaxoSmithKline $3 billion in 2012, for withholding data, unlawfully promoting use in those under 18, and preparing an article that misleadingly reported the effects of paroxetine in adolescent with depression following its clinical trial study 329.[16][17][18]

    Medical uses

    Paroxetine is primarily used to treat major depressive disorder, obsessive-compulsive disorder, post-traumatic stress disorder, social anxiety disorder, panic disorder. It could be used also for agoraphobia, generalized anxiety disorder, premenstrual dysphoric disorder and menopausal hot flashes.[19][20][21][22][23]

    Depression

    A variety of meta analyses have been conducted to evaluate the efficacy of paroxetine in depression. They have variously concluded that paroxetine is superior or equivalent to placebo and that it is equivalent or inferior to other antidepressants.[24][25][26] Despite this, there was no clear evidence that paroxetine was better or worse compared with other antidepressants at increasing response to treatment at any time point.[27]

    Anxiety disorders

    Paroxetine was the first antidepressant approved in the United States for the treatment of panic disorder.[28] Several studies have concluded that paroxetine is superior to placebo in the treatment of panic disorder.[26][29]

    Paroxetine has demonstrated efficacy for the treatment of social anxiety disorder in adults and children.[30][31] It is also beneficial for people with co-occurring social anxiety disorder and alcohol use disorder.[32] It appears to be similar to a number of other SSRIs.[33]

    Paroxetine is used in the treatment of obsessive-compulsive disorder.[34] Comparative efficacy of paroxetine is equivalent to that of clomipramine and venlafaxine.[35][36] Paroxetine is also effective for children with obsessive-compulsive disorder.[37]

    Paroxetine is approved for treatment of PTSD in the United States, Japan and Europe.[38][39][40] In the United States it is approved for short term use.[39]

    Paroxetine is also FDA-approved for generalized anxiety disorder.[41]

    Menopausal hot flashes

    In 2013, low-dose paroxetine was approved in the US for the treatment of moderate-to-severe vasomotor symptoms such as hot flashes and night sweats associated with menopause.[7] At the low dose used for menopausal hot flashes, side effects are similar to placebo and dose tapering is not required for discontinuation.[42]

    Dosage

    The defined daily dose is 20 mg by mouth.[2] In adults for depression typically 20 mg at night is used.[43] This may be increased to 40 mg if insufficiently effective.[43]

    For anxiety 10 to 20 mg is typically used.[43]

    Side effects

    See also: List of adverse effects of paroxetine

    Common side effects include drowsiness, dry mouth, loss of appetite, sweating, trouble sleeping, and sexual dysfunction.[1] Serious side effects may include suicide in those under the age of 25, serotonin syndrome, and mania.[1] While rate of side effects appear similar compared to other SSRIs and SNRIs, antidepressant discontinuation syndromes may occur more often.[8][9] Use in pregnancy is not recommended while use during breastfeeding is relatively safe.[10]

    Paroxetine shares many of the common adverse effects of SSRIs, including (with the corresponding rates seen in people treated with placebo in parentheses): nausea 26% (9%), diarrhea 12% (8%), constipation 14% (9%), dry mouth 18% (12%), somnolence 23% (9%), insomnia 13% (6%), headache 18% (17%), hypomania 1% (0.3%), blurred vision 4%(1%), loss of appetite 6% (2%), nervousness 5% (3%), paraesthesia 4% (2%), dizziness 13% (6%), asthenia (weakness; 15% (6%)), tremor 8% (2%), sweating 11% (2%), and sexual dysfunction (≥10% incidence).[6] Most of these adverse effects are transient and go away with continued treatment. Central and peripheral 5-HT3 receptor stimulation is believed to result in the gastrointestinal effects observed with SSRI treatment.[44] Compared to other SSRIs, it has a lower incidence of diarrhea, but a higher incidence of anticholinergic effects (e.g., dry mouth, constipation, blurred vision, etc.), sedation/somnolence/drowsiness, sexual side effects, and weight gain.[45]

    Due to reports of adverse withdrawal reactions upon terminating treatment, the Committee for Medicinal Products for Human Use (CHMP) at the European Medicines Agency recommends gradually reducing over several weeks or months if the decision to withdraw is made.[46] See also Discontinuation syndrome (withdrawal).

    Mania or hypomania may occur in 1% of patients with depression and up to 12% of patients with bipolar disorder.[47] This side effect can occur in individuals with no history of mania but it may be more likely to occur in those with bipolar or with a family history of mania.[48]

    Suicide

    Like other antidepressants, paroxetine may increase the risk of suicidal thinking and behaviour in children and adolescents.[49][50] The FDA conducted a statistical analysis of paroxetine clinical trials in children and adolescents in 2004 and found an increase in suicidality and ideation as compared to placebo, which was observed in trials for both depression and anxiety disorders.[51] In 2015 a paper published in The BMJ that reanalysed the original case notes argued that in Study 329,[52] assessing paroxetine and imipramine against placebo in adolescents with depression, the incidence of suicidal behavior had been under-reported and the efficacy exaggerated for paroxetine.[53][54][55][56][57]

    Sexual dysfunction

    See also: Selective serotonin reuptake inhibitor § Sexual dysfunction

    Sexual dysfunction, including loss of libido, anorgasmia, lack of vaginal lubrication, and erectile dysfunction, is one of the most commonly encountered adverse effects of treatment with paroxetine and other SSRIs. While early clinical trials suggested a relatively low rate of sexual dysfunction, more recent studies in which the investigator actively inquires about sexual problems suggest that the incidence is higher than 70%.[58] Symptoms of sexual dysfunction have been reported to persist after discontinuing SSRIs, although this is thought to be occasional.[59][60][61]

    Pregnancy

    Antidepressant exposure (including paroxetine) is associated with shorter duration of pregnancy (by three days), increased risk of preterm delivery (by 55%), lower birth weight (by 75 g), and lower Apgar scores (by <0.4 points).[62][63] The American College of Obstetricians and Gynecologists recommends that for pregnant women and women planning to become pregnant, "be avoided, if possible", as paroxetine may be associated with increased risk of birth defects.[64][64][65]

    Babies born to women who used paroxetine during the first trimester paroxetine have an increased risk of cardiovascular malformations, primarily ventricular and atrial septal defects (VSDs and ASDs). Unless the benefits of paroxetine justify continuing treatment, consideration should be given to stopping or switching to another antidepressant.[66] Paroxetine use during pregnancy is associated with about 1.5–1.7-fold increase in congenital birth defects, in particular, heart defects.[67][68][69][70][71]

    Discontinuation syndrome

    See also: SSRI discontinuation syndrome

    Many psychoactive medications can cause withdrawal symptoms upon discontinuation from administration. Evidence has shown that paroxetine has among the highest incidence rates and severity of withdrawal syndrome of any medication of its class.[72] Common withdrawal symptoms for paroxetine include nausea, dizziness, lightheadedness and vertigo; insomnia, nightmares and vivid dreams; feelings of electricity in the body, as well as rebound depression and anxiety. Liquid formulation of paroxetine is available and allows a very gradual decrease of the dose, which may prevent discontinuation syndrome. Another recommendation is to temporarily switch to fluoxetine, which has a longer half-life and thus decreases the severity of discontinuation syndrome.[73][74][75]

    In 2002 the U.S. FDA published a warning regarding "severe" discontinuation symptoms among those terminating paroxetine treatment, including paraesthesia, nightmares, and dizziness. The Agency also warned of case reports describing agitation, sweating, and nausea. In connection with a Glaxo spokesperson's statement that withdrawal reactions occur only in 0.2% of patients and are "mild and short-lived", the International Federation of Pharmaceutical Manufacturers Associations said GSK had breached two of the Federation's codes of practice.[76]

    Paroxetine prescribing information posted at GlaxoSmithKline now acknowledges the occurrence of a discontinuation syndrome, including serious discontinuation symptoms.[66]

    Overdose

    Acute overdosage is often manifested by emesis, lethargy, ataxia, tachycardia, and seizures. Plasma, serum, or blood concentrations of paroxetine may be measured to monitor therapeutic administration, confirm a diagnosis of poisoning in hospitalized patients or to aid in the medicolegal investigation of fatalities. Plasma paroxetine concentrations are generally in a range of 40–400 μg/L in persons receiving daily therapeutic doses and 200–2,000 μg/L in poisoned patients. Postmortem blood levels have ranged from 1–4 mg/L in acute lethal overdose situations.[77][78] Along with the other SSRIs, sertraline and fluoxetine, paroxetine is considered a low-risk drug in cases of overdose.[79]

    Interactions

    Interactions with other drugs acting on the serotonin system or impairing the metabolism of serotonin may increase the risk of Serotonin Syndrome or Neuroleptic Malignant Syndrome (NMS)-like reaction. Such reactions have been observed with SNRIs and SSRIs alone, but particularly with concurrent use of triptans, MAO inhibitors, antipsychotics, or other dopamine antagonists.

    The prescribing information states that paroxetine should "not be used in combination with an MAOI (including linezolid, an antibiotic which is a reversible non-selective MAOI), or within 14 days of discontinuing treatment with an MAOI", and should not be used in combination with pimozide, thioridazine, tryptophan, or warfarin.[66]

    Paroxetine interacts with the following cytochrome P450 enzymes:[45][80]

    Paroxetine has been shown to be an inhibitor of G protein-coupled receptor kinase 2 (GRK2).[81][82]

    Pharmacology

    Mechanism of paroxetine inhibition of CYP2D6.[83]

    Pharmacodynamics

    Paroxetine is the most potent and one of the most specific selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors (SSRIs).[84] It also binds to the allosteric site of the serotonin transporter, similarly, but less potently, than escitalopram.[85] Paroxetine also inhibits the reuptake of norepinephrine to a lesser extent (<50 nmol/L).[86] Based on evidence from four weeks of administration in rats, the equivalent of 20 mg paroxetine taken once daily occupies approximately 88% of serotonin transporters in the prefrontal cortex.[80]

    Binding profile[44][80][87][88]
    ReceptorKi (nM)
    SERT1.6
    NET6210
    DAT4900
    D28.0
    5-HT1A416
    5-HT2A0.17
    5-HT2C12.0
    α12,741
    α23,900
    M1720
    M2340
    M3800
    M4320
    M5650
    H1>100

    Pharmacokinetics

    Paroxetine is well-absorbed following oral administration.[80] It has an absolute bioavailability of about 50%, with evidence of a saturable first-pass effect.[89] When taken orally, it achieves maximum concentration in about 6–10 hours[80] and reaches steady-state in 7–14 days.[89] Paroxetine exhibits significant interindividual variations in volume of distribution and clearance.[89] Less than 2% of an oral dose is excreted in urine unchanged.[89]

    Paroxetine is a mechanism-based inhibitor of CYP2D6.[83][90]

    Metabolism of paroxetine in humans.[90]

    Society and culture

    GlaxoSmithKline has paid substantial fines, paid settlements in class-action lawsuits, and become the subject of several highly critical books about its marketing of paroxetine, in particular the off-label marketing of paroxetine for children, the suppression of negative research results relating to its use in children, and allegations that it failed to warn consumers of substantial withdrawal effects associated with use of the drug.[16][17] Paroxetine was approved for medical use in the United States in 1992 and initially sold by GlaxoSmithKline.[1][91] It is currently available as a generic medication.[12] The United States Department of Justice fined GlaxoSmithKline $3 billion in 2012, for withholding data, unlawfully promoting use in those under 18, and preparing an article that misleadingly reported the effects of paroxetine in adolescents with depression following its clinical trial study 329.[16][17][18]

    Cost

    A month supply in the United Kingdom costs the NHS about 1.10 £ per month as of 2019.[12] In the United States the wholesale cost of this amount is about US$2.40.[13] In 2017, it was the 68th most commonly prescribed medication in the United States, with more than eleven million prescriptions.[14][15]

    • Paroxetine costs (US)
    • Paroxetine prescriptions (US)

    Marketing

    See also: Study 329

    In early 2004, GSK agreed to settle charges of consumer fraud for $2.5 million.[92] The legal discovery process also uncovered evidence of deliberate, systematic suppression of unfavorable Paxil research results. One of GSK's internal documents read, "It would be commercially unacceptable to include a statement that efficacy [in children] had not been demonstrated, as this would undermine the profile of paroxetine".[93]

    In 2012 the U.S. Justice Department announced that GSK agreed to plead guilty and pay a $3 billion fine, in part for promoting the use of Paxil for children.[18]

    On 12 February 2016, the UK Competition and Markets Authority imposed record fines of £45 million on companies which were found to have infringed European Union and UK Competition law by entering into agreements to delay the market entry of generic versions of the drug in the UK. GlaxoSmithKline received the bulk of the fines, being fined £37,600,757. Other companies, which produce generics, were issued fines which collectively total £7,384,146. UK public health services are likely to claim damages for being overcharged in the period where the generic versions of the drug were illegally blocked from the market, as the generics are over 70% less expensive. GlaxoSmithKline may also face actions from other generics manufacturers who incurred loss as a result of the anticompetitive conduct.[94] On 18 April 2016, appeals were lodged with the Competition Appeal Tribunal by the companies which were fined.[95][96][97][98][99]

    GSK marketed paroxetine through television advertisements throughout the late 1990s and early 2000s. Commercials also aired for the CR version of the drug beginning in 2003.[100]

    Sales

    In 2007, paroxetine was ranked 94th on the list of bestselling drugs, with over $1 billion in sales. In 2006, paroxetine was the fifth-most prescribed antidepressant in the U.S. retail market, with more than 19.7 million prescriptions.[101] In 2007, sales had dropped slightly to 18.1 million but paroxetine remained the fifth-most prescribed antidepressant in the U.S.[102][103]

    Trade names

    Trade names include Aropax, Brisdelle, Deroxat, Paxil,[104][105] Pexeva, Paxtine, Paxetin, Paroxat, Paraxyl,[106] Sereupin, Daparox and Seroxat. It is marketed by Sebela Pharmaceuticals under the brand name Brisdelle.[42]

    Research

    Several studies have suggested that paroxetine can be used in the treatment of premature ejaculation. In particular, intravaginal ejaculation latency time (IELT) was found to increase with 6–13-fold, which was somewhat longer than the delay achieved by the treatment with other SSRIs (fluvoxamine, fluoxetine, sertraline, and citalopram).[107][108][109] However, paroxetine taken acutely ("on demand") 3–10 hours before coitus resulted only in a "clinically irrelevant and sexually unsatisfactory" 1.5-fold delay of ejaculation and was inferior to clomipramine, which induced a fourfold delay.[109]

    There is also evidence that paroxetine may be effective in the treatment of compulsive gambling[110] and hot flashes.[111]

    Benefits of paroxetine prescription for diabetic neuropathy[112] or chronic tension headache[113] are uncertain.

    Although the evidence is conflicting, paroxetine may be effective for the treatment of dysthymia, a chronic disorder involving depressive symptoms for most days of the year.[114]

    There is evidence to support that paroxetine selectively binds to and inhibits G protein-coupled receptor kinase 2 (GRK2). Since GRK2 regulates the activity of the beta adrenergic receptor, which becomes desensitized in cases of heart failure, paroxetine (or a paroxetine derivative) could be used as a heart failure treatment in the future.[81][82]

    See also

    • List of medical ethics cases

    References

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