Alpha-5 beta-1

α₅β₁, also known as the fibronectin receptor,[1] is an integrin that binds to matrix macromolecules and proteinases and thereby stimulates angiogenesis.[2] It is composed of α₅ (ITGA5/CD49e) and β₁ (ITGB1/CD29) subunits. It is the primary receptor for fibronectin. The interaction of VLA-5 with fibronectin plays an important role in regulating inflammatory cytokine production by human articular chondrocytes (From the Cell Migration Gateway ITGA5 ITGB1).

α₅β₁-integrin is transported inside the cell by the kinesin KIF1C,[3] a kinesin-3 organelle transporter that walks along microtubules.

References

Schaffner, F.; Ray, A.; Dontenwill, M. (2013). "Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors". Cancers. 5 (4): 27–47. doi:10.3390/cancers5010027. PMC 3730317.
Boudreau NJ, Varner JA (February 2004). "The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis". J. Biol. Chem. 279 (6): 4862–8. doi:10.1074/jbc.M305190200. PMID 14610084.
Theisen, U; Straube, E; Straube, A (Dec 11, 2012). "Directional persistence of migrating cells requires Kif1C-mediated stabilization of trailing adhesions". Developmental Cell. 23 (6): 1153–66. doi:10.1016/j.devcel.2012.11.005. PMID 23237952.

External links

Integrin+alpha5beta1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
ITGA5 ITGB1 Info with links in the Cell Migration Gateway

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] Schaffner, F.; Ray, A.; Dontenwill, M. (2013). "Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors". Cancers. 5 (4): 27–47. doi:10.3390/cancers5010027. PMC 3730317.

[pmid14610084-2] Boudreau NJ, Varner JA (February 2004). "The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis". J. Biol. Chem. 279 (6): 4862–8. doi:10.1074/jbc.M305190200. PMID 14610084.

[3] Theisen, U; Straube, E; Straube, A (Dec 11, 2012). "Directional persistence of migrating cells requires Kif1C-mediated stabilization of trailing adhesions". Developmental Cell. 23 (6): 1153–66. doi:10.1016/j.devcel.2012.11.005. PMID 23237952.