5-dehydro-2-deoxygluconokinase

In enzymology, a 5-dehydro-2-deoxygluconokinase (EC 2.7.1.92) is an enzyme that catalyzes the chemical reaction

ATP + 5-dehydro-2-deoxy-D-gluconate ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate
5-dehydro-2-deoxygluconokinase
Identifiers
EC no.2.7.1.92
CAS no.62213-35-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are ATP and 5-dehydro-2-deoxy-D-gluconate, whereas its two products are ADP and 6-phospho-5-dehydro-2-deoxy-D-gluconate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase. Other names in common use include 5-keto-2-deoxygluconokinase, 5-keto-2-deoxyglucono kinase (phosphorylating), and DKH kinase. This enzyme participates in inositol metabolism.

References

    • Anderson WA, Magasanik B (1971). "The pathway of myo-inositol degradation in Aerobacter aerogenes Conversion of 2-deoxy-5-keto-D-gluconic acid to glycolytic intermediates". J. Biol. Chem. 246 (18): 5662–75. PMID 4328832.


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