AKT3

RAC-gamma serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT3 gene.[5][6]

AKT3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAKT3, MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2, AKT serine/threonine kinase 3
External IDsOMIM: 611223 MGI: 1345147 HomoloGene: 55904 GeneCards: AKT3
Orthologs
SpeciesHumanMouse
Entrez

10000

23797

Ensembl

ENSG00000117020
ENSG00000275199

ENSMUSG00000019699

UniProt

Q9Y243

Q9WUA6

RefSeq (mRNA)

NM_001206729
NM_005465
NM_181690
NM_001370074

NM_011785

RefSeq (protein)

NP_001193658
NP_005456
NP_859029
NP_001357003

NP_035915

Location (UCSC)Chr 1: 243.49 – 243.85 MbChr 1: 176.85 – 177.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the AKT subfamily of serine/threonine protein kinases. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.[7] Mice lacking Akt3 have a normal glucose metabolism (no diabetes), have approximately normal body weight, but have a 25% reduction in brain mass. Incidentally, Akt3 is highly expressed in the brain.

Interactions

AKT3 has been shown to interact with Protein kinase Mζ.[8]

References

  1. ENSG00000275199 GRCh38: Ensembl release 89: ENSG00000117020, ENSG00000275199 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000019699 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Brodbeck D, Cron P, Hemmings BA (Apr 1999). "A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain". J Biol Chem. 274 (14): 9133–6. doi:10.1074/jbc.274.14.9133. PMID 10092583.
  6. Nakatani K, Sakaue H, Thompson DA, Weigel RJ, Roth RA (Jun 1999). "Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site". Biochem Biophys Res Commun. 257 (3): 906–10. doi:10.1006/bbrc.1999.0559. PMID 10208883.
  7. "Entrez Gene: AKT3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)".
  8. Hodgkinson CP, Sale EM, Sale GJ (2002). "Characterization of PDK2 activity against protein kinase B gamma". Biochemistry. 41 (32): 10351–9. doi:10.1021/bi026065r. PMID 12162751.

Further reading

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