Inhibitor of apoptosis domain

The inhibitor of apoptosis domain -- also known as IAP repeat, Baculovirus Inhibitor of apoptosis protein Repeat, or BIR -- is a structural motif found in proteins with roles in apoptosis, cytokine production, and chromosome segregation.[2] Proteins containing BIR are known as inhibitor of apoptosis proteins (IAPs), or BIR-containing proteins (BIRPs or BIRCs), and include BIRC1 (NAIP), BIRC2 (cIAP1), BIRC3 (cIAP2), BIRC4 (xIAP), BIRC5 (survivin) and BIRC6.[2][3]

Inhibitor of Apoptosis domain
NMR solution structure of the BIR domain of human BIRC2 protein.[1] The protein is rainbow colored cartoon diagram (N-terminus = blue, C-terminus = red) while the coordinated zinc is represented by a grey sphere.
Identifiers
SymbolBIR
PfamPF00653
InterProIPR001370
PROSITEPS50143
SCOP21qbh / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1c9q, 1e31, 1f3h, 1f9x, 1g3f, 1g73, 1i3o, 1jd4, 1jd5, 1jd6, 1m4m, 1nw9, 1oxn, 1oxq, 1oy7, 1q4q, 1qbh, 1sdz, 1se0, 1tfq, 1tft, 1tw6, 1xb0, 1xb1, 1xox, 2i3h, 2i3i

BIR domains belong to the zinc-finger domain family and characteristically have a number of invariant amino acid residues, including 3 conserved cysteines and one conserved histidine, which coordinate a zinc ion.[4] They are typically composed of 4-5 alpha helices and a three-stranded beta sheet.

References

  1. PDB: 1QBH;Hinds MG, Norton RS, Vaux DL, Day CL (July 1999). "Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat". Nat. Struct. Biol. 6 (7): 648–51. doi:10.1038/10701. PMID 10404221. S2CID 3194182.
  2. Silke J, Vaux DL (May 2001). "Two kinds of BIR-containing protein - inhibitors of apoptosis, or required for mitosis". J. Cell Sci. 114 (Pt 10): 1821–7. PMID 11329368.
  3. Verhagen AM, Coulson EJ, Vaux DL (2001). "Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs". Genome Biol. 2 (7): REVIEWS3009. doi:10.1186/gb-2001-2-7-reviews3009. PMC 139420. PMID 11516343.
  4. Birnbaum MJ, Clem RJ, Miller LK (April 1994). "An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs". J. Virol. 68 (4): 2521–8. doi:10.1128/JVI.68.4.2521-2528.1994. PMC 236730. PMID 8139034.
This article incorporates text from the public domain Pfam and InterPro: IPR001370
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