Kinase binding protein CGI-121
In molecular biology, the kinase binding protein CGI-121 family of proteins includes the kinase binding protein CGI-121 and its homologues. CGI-121 has been shown to bind to the p53-related protein kinase (PRPK).[1] CGI-121 is part of a conserved protein complex, KEOPS. The KEOPS complex is involved in telomere uncapping and telomere elongation.[2] This family of proteins also include archaeal homologues.
| CGI-121 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of pfu-542154 conserved hypothetical protein | |||||||||
| Identifiers | |||||||||
| Symbol | CGI-121 | ||||||||
| Pfam | PF08617 | ||||||||
| InterPro | IPR013926 | ||||||||
| SCOP2 | 1zd0 / SCOPe / SUPFAM | ||||||||
| |||||||||
References
- Miyoshi A, Kito K, Aramoto T, Abe Y, Kobayashi N, Ueda N (April 2003). "Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein". Biochem. Biophys. Res. Commun. 303 (2): 399–405. doi:10.1016/S0006-291X(03)00333-4. PMID 12659830.
- Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D (March 2006). "A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator". Cell. 124 (6): 1155–68. doi:10.1016/j.cell.2005.12.044. PMID 16564010. S2CID 13928061.
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