CHRNA10

CHRNA10
Identifiers
Aliases	CHRNA10, cholinergic receptor nicotinic alpha 10 subunit
External IDs	OMIM: 606372 MGI: 3609260 HomoloGene: 56886 GeneCards: CHRNA10
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	3,671,384 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	101,766,035 bp[2]
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; blood; ; right lobe of liver; ; cerebellar hemisphere; ; spleen; ; right lobe of thyroid gland; ; stromal cell of endometrium; ; left ventricle; ; gastric mucosa; ; body of stomach;
	Top expressed in
	olfactory bulb; ; muscle tissue; ; quadriceps femoris muscle; ; skeletal muscle tissue; ; spermatocyte; ; lip; ; esophagus; ; thymus; ; zone of skin; ; heart;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium channel activity; ion channel activity; signaling receptor binding; extracellular ligand-gated ion channel activity; acetylcholine-gated cation-selective channel activity; transmembrane signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; perikaryon; postsynaptic membrane; membrane; plasma membrane; synapse; axon; cell junction; cholinergic synapse; integral component of postsynaptic specialization membrane; integral component of plasma membrane; neuron projection;
Biological process	positive regulation of cytosolic calcium ion concentration; synaptic transmission, cholinergic; ion transport; detection of mechanical stimulus involved in sensory perception of sound; regulation of cell population proliferation; calcium ion transmembrane transport; inner ear morphogenesis; calcium ion transport; regulation of postsynaptic membrane potential; excitatory postsynaptic potential; signal transduction; ion transmembrane transport; negative regulation of ERK1 and ERK2 cascade; chemical synaptic transmission; regulation of membrane potential; nervous system process;
	Sources:Amigo / QuickGO
Orthologs
	57053
	504186
	ENSG00000129749
	ENSMUSG00000066279
	Q9GZZ6
	n/a
	NM_001303034; NM_001303035; NM_020402
	NM_001081424
	NP_001289963; NP_001289964; NP_065135
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-10, also known as nAChRα10 and cholinergic receptor nicotinic alpha 10, is a protein that in humans is encoded by the CHRNA10 gene.[5] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

This nAchR subunit is required for the normal function of the olivocochlear system which is part of the auditory system.[6] Furthermore, selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.[7]

α10 subunit-containing receptors are notably blocked by nicotine. The role of this antagonism in the effects of tobacco are unknown.

References

GRCh38: Ensembl release 89: ENSG00000129749 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000066279 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lustig LR, Peng H, Hiel H, Yamamoto T, Fuchs PA (May 2001). "Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10)". Genomics. 73 (3): 272–83. doi:10.1006/geno.2000.6503. PMID 11350119.
Vetter DE, Katz E, Maison SF, Taranda J, Turcan S, Ballestero J, Liberman MC, Elgoyhen AB, Boulter J (December 2007). "The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system". Proc. Natl. Acad. Sci. U.S.A. 104 (51): 20594–9. doi:10.1073/pnas.0708545105. PMC 2154476. PMID 18077337.
Vincler M, Wittenauer S, Parker R, Ellison M, Olivera BM, McIntosh JM (November 2006). "Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors". Proc. Natl. Acad. Sci. U.S.A. 103 (47): 17880–4. Bibcode:2006PNAS..10317880V. doi:10.1073/pnas.0608715103. PMC 1635975. PMID 17101979.

External links

CHRNA10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CHRNA10 genome location and CHRNA10 gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129749 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000066279 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11350119-5] Lustig LR, Peng H, Hiel H, Yamamoto T, Fuchs PA (May 2001). "Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10)". Genomics. 73 (3): 272–83. doi:10.1006/geno.2000.6503. PMID 11350119.

[pmid18077337-6] Vetter DE, Katz E, Maison SF, Taranda J, Turcan S, Ballestero J, Liberman MC, Elgoyhen AB, Boulter J (December 2007). "The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system". Proc. Natl. Acad. Sci. U.S.A. 104 (51): 20594–9. doi:10.1073/pnas.0708545105. PMC 2154476. PMID 18077337.

[pmid17101979-7] Vincler M, Wittenauer S, Parker R, Ellison M, Olivera BM, McIntosh JM (November 2006). "Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors". Proc. Natl. Acad. Sci. U.S.A. 103 (47): 17880–4. Bibcode:2006PNAS..10317880V. doi:10.1073/pnas.0608715103. PMC 1635975. PMID 17101979.