P2RX6

P2RX6
Identifiers
Aliases	P2RX6, P2RXL1, P2X6, P2XM, purinergic receptor P2X 6
External IDs	OMIM: 608077 MGI: 1337113 HomoloGene: 3975 GeneCards: P2RX6
Gene location (Human)
Chr.	Chromosome 22 (human)[1]
End	21,028,013 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	17,395,664 bp[2]
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; right uterine tube; ; Brodmann area 9; ; spleen; ; anterior pituitary; ; prefrontal cortex; ; right adrenal gland; ; right coronary artery; ; hypothalamus; ; substantia nigra;
	Top expressed in
	facial motor nucleus; ; skeletal muscle tissue; ; soleus muscle; ; quadriceps femoris muscle; ; morula; ; temporal muscle; ; masseter muscle; ; anterior horn of spinal cord; ; vastus lateralis muscle; ; intercostal muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	channel activity; purinergic nucleotide receptor activity; extracellularly ATP-gated cation channel activity; ion channel activity; identical protein binding; ATP binding; transmembrane signaling receptor activity; ATP-gated ion channel activity;
Cellular component	cytoplasm; integral component of membrane; membrane; integral component of nuclear inner membrane; integral component of plasma membrane; cell junction; plasma membrane; postsynapse; postsynaptic density; neuronal cell body; dendritic spine; parallel fiber to Purkinje cell synapse; glutamatergic synapse; integral component of postsynaptic specialization membrane;
Biological process	response to ATP; muscle contraction; ion transport; cation transmembrane transport; protein homooligomerization; signal transduction; blood coagulation; purinergic nucleotide receptor signaling pathway; excitatory postsynaptic potential; protein heterooligomerization; cation transport; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	9127
	18440
	ENSG00000099957
	ENSMUSG00000022758
	O15547
	O54803
NM_001159554; NM_005446; NM_001349874; NM_001349875; NM_001349876;
	NM_001394691; NM_001394692; NM_001394693; NM_001394694; NM_001394695; NM_001394696; NM_001394697
	NM_001159561; NM_011028
	NP_001153026; NP_005437; NP_001336803; NP_001336804; NP_001336805
	NP_001153033; NP_035158
	Wikidata
View/Edit Human	View/Edit Mouse

P2X purinoceptor 6 is a protein that in humans is encoded by the P2RX6 gene.[5][6][7][8]

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells.[8]

References

GRCh38: Ensembl release 89: ENSG00000099957 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022758 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y, Tokino T (Sep 1997). "Cloning of P2XM, a novel human P2X receptor gene regulated by p53". Cancer Res. 57 (15): 3281–7. PMID 9242461.
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G (Sep 1996). "Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels". J Neurosci. 16 (8): 2495–507. doi:10.1523/JNEUROSCI.16-08-02495.1996. PMC 6578782. PMID 8786426.
"Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor".

External links

P2RXL1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099957 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022758 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9242461-5] Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y, Tokino T (Sep 1997). "Cloning of P2XM, a novel human P2X receptor gene regulated by p53". Cancer Res. 57 (15): 3281–7. PMID 9242461.

[pmid10591208-6] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.

[pmid8786426-7] Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G (Sep 1996). "Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels". J Neurosci. 16 (8): 2495–507. doi:10.1523/JNEUROSCI.16-08-02495.1996. PMC 6578782. PMID 8786426.

[entrez-8] "Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor".

P2RX6

See also

References

Further reading

External links