Chimerin 2

Chimerin 2 (beta-chimaerin) is a protein that in humans is encoded by the CHN2 gene.[4][5]

CHN2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCHN2, ARHGAP3, BCH, CHN2-3, RHOGAP3, chimerin 2
External IDsOMIM: 602857 MGI: 1917243 HomoloGene: 31213 GeneCards: CHN2
Orthologs
SpeciesHumanMouse
Entrez

1124

69993

Ensembl

ENSG00000106069

ENSMUSG00000004633

UniProt

P52757

Q80XD1

RefSeq (mRNA)

NM_001163640
NM_023543
NM_001311133
NM_001311134

RefSeq (protein)

NP_001157112
NP_001298062
NP_001298063
NP_076032

Location (UCSC)n/aChr 6: 54.02 – 54.28 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/diacylglycerol-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[5]

References

  1. GRCm38: Ensembl release 89: ENSMUSG00000004633 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Leung T, How BE, Manser E, Lim L (Jun 1994). "Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain". J Biol Chem. 269 (17): 12888–92. doi:10.1016/S0021-9258(18)99959-X. PMID 8175705.
  5. "Entrez Gene: CHN2 chimerin (chimaerin) 2".

Further reading


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