Cyanidin-3-O-glucoside 2-O-glucuronosyltransferase

Cyanidin-3-O-glucoside 2-O-glucuronosyltransferase (EC 2.4.1.254, BpUGT94B1, UDP-glucuronic acid:anthocyanin glucuronosyltransferase, UDP-glucuronic acid:anthocyanidin 3-glucoside 2'-O-beta-glucuronosyltransferase, BpUGAT, UDP-D-glucuronate:cyanidin-3-O-beta-glucoside 2-O-beta-glucuronosyltransferase) is an enzyme with systematic name UDP-D-glucuronate:cyanidin-3-O-beta-D-glucoside 2-O-beta-D-glucuronosyltransferase.[1][2] This enzyme catalyses the following chemical reaction

UDP-D-glucuronate + cyanidin 3-O-beta-D-glucoside UDP + cyanidin 3-O-(2-O-beta-D-glucuronosyl)-beta-D-glucoside
Cyanidin-3-O-glucoside 2-O-glucuronosyltransferase
Identifiers
EC no.2.4.1.254
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme is highly specific for cyanidin 3-O-glucosides and UDP-D-glucuronate.

References
  1. Sawada S, Suzuki H, Ichimaida F, Yamaguchi MA, Iwashita T, Fukui Y, Hemmi H, Nishino T, Nakayama T (January 2005). "UDP-glucuronic acid:anthocyanin glucuronosyltransferase from red daisy (Bellis perennis) flowers. Enzymology and phylogenetics of a novel glucuronosyltransferase involved in flower pigment biosynthesis". The Journal of Biological Chemistry. 280 (2): 899–906. doi:10.1074/jbc.m410537200. PMID 15509561.
  2. Osmani SA, Bak S, Imberty A, Olsen CE, Møller BL (November 2008). "Catalytic key amino acids and UDP-sugar donor specificity of a plant glucuronosyltransferase, UGT94B1: molecular modeling substantiated by site-specific mutagenesis and biochemical analyses". Plant Physiology. 148 (3): 1295–308. doi:10.1104/pp.108.128256. PMC 2577238. PMID 18829982.
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