Cyclic AMP receptors

Cyclic AMP receptors from slime molds are a distinct family of G-protein coupled receptors. These receptors control development in Dictyostelium discoideum.

Slime mold cyclic AMP receptor
Identifiers
SymbolDicty_CAR
PfamPF05462
Pfam clanCL0192
InterProIPR000848
PROSITEPDOC00691
CDDcd14940
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

In D. discoideum, the cyclic AMP receptors coordinate aggregation of individual cells into a multicellular organism, and regulate the expression of a large number of developmentally-regulated genes.[1][2][3] The amino acid sequences of the receptors contain high proportions of hydrophobic residues grouped into 7 domains, in a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins. However, while a similar 3D framework has been proposed to account for this, there is no significant sequence similarity between these families: the cAMP receptors thus bear their own unique '7TM' signature.

See also

References

  1. Devreotes PN, Kimmel AR, Johnson RL, Klein PS, Sun TJ, Saxe III CL (1988). "A chemoattractant receptor controls development in Dictyostelium discoideum". Science. 241 (4872): 1467–1472. Bibcode:1988Sci...241.1467K. doi:10.1126/science.3047871. PMID 3047871.
  2. Ginsburg GT, Louis JM, Johnson R, Devreotes PN, Kimmel AR, Saxe III CL (1993). "CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum". Genes Dev. 7 (2): 262–272. doi:10.1101/gad.7.2.262. PMID 8436297.
  3. Devreotes PN, Kimmel AR, Johnson RL, Gollop R, Saxe III CL (1993). "Identification and targeted gene disruption of cAR3, a cAMP receptor subtype expressed during multicellular stages of Dictyostelium development". Genes Dev. 7 (2): 273–282. doi:10.1101/gad.7.2.273. PMID 8382181.


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