DIS3L

DIS3L
Identifiers
Aliases	DIS3L, DIS3L1, DIS3 like exosome 3'-5' exoribonuclease
External IDs	OMIM: 614183 MGI: 2143272 HomoloGene: 15797 GeneCards: DIS3L
Gene location (Human)
Chr.	Chromosome 15 (human)[1]
End	66,333,898 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	64,248,570 bp[2]
RNA expression pattern
	Top expressed in
	corpus callosum; ; tibialis anterior muscle; ; deltoid muscle; ; vastus lateralis muscle; ; Achilles tendon; ; inferior ganglion of vagus nerve; ; superior surface of tongue; ; gastrocnemius muscle; ; body of tongue; ; subthalamic nucleus;
	Top expressed in
	spermatocyte; ; spermatid; ; secondary oocyte; ; seminiferous tubule; ; interventricular septum; ; hand; ; proximal tubule; ; muscle tissue; ; renal corpuscle; ; skeletal muscle tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	enzyme binding; nuclease activity; exonuclease activity; protein binding; hydrolase activity; RNA binding; 3'-5'-exoribonuclease activity; endonuclease activity; ribonuclease activity;
Cellular component	cytoplasmic exosome (RNase complex); centrosome; plasma membrane; exosome (RNase complex); cytoplasm; cytosol; nuclear exosome (RNase complex);
Biological process	rRNA processing; RNA phosphodiester bond hydrolysis, exonucleolytic; rRNA catabolic process; RNA catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	115752
	213550
	ENSG00000166938
	ENSMUSG00000032396
	Q8TF46
	Q8C0S1
NM_001143688; NM_133375; NM_001323936; NM_001323937; NM_001323938;
	NM_001323939; NM_001323940; NM_001323941; NM_001323943; NM_001323944; NM_001323945; NM_001323946; NM_001323948
	NM_001001295; NM_001177784; NM_172519
NP_001137160; NP_001310865; NP_001310866; NP_001310867; NP_001310868;
	NP_001310869; NP_001310870; NP_001310872; NP_001310873; NP_001310874; NP_001310875; NP_001310877; NP_588616
	NP_001001295; NP_001171255; NP_766107
	Wikidata
View/Edit Human	View/Edit Mouse

DIS3-like exonuclease 1 (Dis3L1 or Dis3L) is an enzyme that in humans is encoded by the DIS3L gene. Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the cytoplasm of eukaryotic cells.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000166938 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032396 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Staals RH, Bronkhorst AW, Schilders G, Slomovic S, Schuster G, Heck AJ, Raijmakers R, Pruijn GJ (July 2010). "Dis3-like 1: a novel exoribonuclease associated with the human exosome". EMBO J. 29 (14): 2358–67. doi:10.1038/emboj.2010.122. PMC 2910272. PMID 20531389.
Tomecki R, Kristiansen MS, Lykke-Andersen S, Chlebowski A, Larsen KM, Szczesny RJ, Drazkowska K, Pastula A, Andersen JS, Stepien PP, Dziembowski A, Jensen TH (July 2010). "The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L". EMBO J. 29 (14): 2342–57. doi:10.1038/emboj.2010.121. PMC 2910271. PMID 20531386.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166938 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032396 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Staals-5] Staals RH, Bronkhorst AW, Schilders G, Slomovic S, Schuster G, Heck AJ, Raijmakers R, Pruijn GJ (July 2010). "Dis3-like 1: a novel exoribonuclease associated with the human exosome". EMBO J. 29 (14): 2358–67. doi:10.1038/emboj.2010.122. PMC 2910272. PMID 20531389.

[Tomecki-6] Tomecki R, Kristiansen MS, Lykke-Andersen S, Chlebowski A, Larsen KM, Szczesny RJ, Drazkowska K, Pastula A, Andersen JS, Stepien PP, Dziembowski A, Jensen TH (July 2010). "The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L". EMBO J. 29 (14): 2342–57. doi:10.1038/emboj.2010.121. PMC 2910271. PMID 20531386.

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)