DNA alpha-glucosyltransferase

In enzymology, a DNA alpha-glucosyltransferase (EC 2.4.1.26) is an enzyme that catalyzes the chemical reaction in which an alpha-D-glucosyl residue is transferred from UDP-glucose to a hydroxymethylcytosine residue in DNA.

DNA alpha-glucosyltransferase
Identifiers
EC no.2.4.1.26
CAS no.9030-13-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:DNA alpha-D-glucosyltransferase. Other names in common use include uridine diphosphoglucose-deoxyribonucleate, alpha-glucosyltransferase, UDP-glucose-DNA alpha-glucosyltransferase, uridine diphosphoglucose-deoxyribonucleate, alpha-glucosyltransferase, T2-HMC-alpha-glucosyl transferase, T4-HMC-alpha-glucosyl transferase, and T6-HMC-alpha-glucosyl transferase.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1XV5, 1Y6F, 1Y6G, 1Y8Z, and 1YA6.

References

    • Kornberg SR, Zimmerman SB, Kornberg A (1961). "Glucosylation of deoxyribonucleic acid by enzymes from bacteriophage-infected Escherichia coli". J. Biol. Chem. 236: 1487–1493. PMID 13753193.


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