Dan Vs.

• Dan (voiced by Curtis Armstrong) serves as the main protagonist of the series. He is a mismanaged temperamental man with serious anger issues due to a rough childhood. Due to his upbringing, he becomes hostile, short-tempered, impatient, and easily provoked. On most occasions, he conserves himself from any enraged behavior. In nearly all of his revenge missions, Dan calls Chris, over for help. He lives in an apartment hovel in North Hollywood, CA.
• Chris (voiced by Dave Foley) is Dan's best friend and Elise's husband. Despite how much Dan mistreats him, he is almost always on call whenever Dan needs help with one of his revenge schemes. He is a complete pushover, big softy, and almost never can say no to his wife or best friend. He has a nearly uncontrollable appetite and has food on his mind most of the time.
• Elise (voiced by Paget Brewster) is Chris's levelheaded kindhearted wife. She is usually calm and easy going but can become dangerous when provoked and annoyed over-the-line. She is constantly annoyed by Dan's revenge antics, though she rarely tries to stop her husband whenever he goes off to help Dan. Elise works as a covert field agent for an unnamed (but presumably American) 'quasi' government agency and her work for said agency often acts as a subplot in several episodes.
• Mr. Mumbles (vocals by Paget Brewster) is Dan's cat that he rescued from an animal shelter while taking revenge on the unbearably noisy Animal Shelter right across the street being it directly behind his apartment.

• Crunchy (voiced by Tom Kenny) is a dreadlock-wearing hippie who has the misfortune of working as a store clerk in several places that Dan takes revenge on.
• Sheriff (voiced by John DiMaggio) is a big, chubby, tough police man who is seen every time Dan makes reports and false reports. Every time Dan makes trouble, the sheriff uses a taser to shock him.
• Don (voiced by Michael Gross) is Elise's father who runs a successful cupcake store chain and hates Chris to the point of trying to cause Elise to marry another man by various means (usually at Chris's expense).
• Elise Sr. (voiced by Meredith Baxter) is Elise's mother, who dislikes Chris but not quite as much as her husband as she keeps her time and attention to an unspecified Mafia family. At one time, both Elise and Elise Sr. had to fight each other, as their missions were in conflict with each other.
• Ninja Dave (voiced by Eric Bauza) is a former ninja of the Koshugi clan who swore never to bake cookies, thus had to steal them whenever he wanted to eat some and to destroy any rivals of his clan.
• Spy Boss (voiced by Dan Mandel) is the unnamed and unseen boss of Elise who sends her on different missions during specific episodes. It is revealed he is a former super model in the episode "The Common Cold".
• Hortense (voiced by Grey DeLisle) is an airhead employee who works at the Burgerphile restaurant who falls for Dan after he begins a protest against the restaurant. She later returns in "The Wedding" and announces she is to be married to the owner of Burgerphile named Jeremiah Burger which drives Dan insane, as he feels deceived. She is the only person whom Dan consistently treats with kindness.
• The Imposter (voiced by John C. McGinley) is an unnamed man who one day shows up in Dan's apartment claiming to be Dan. He manipulates everyone around him and portrays himself as a "good neighbor" to steal Dan's life. He is later arrested for a crime Dan committed, and swears revenge. He later returns in "The Telemarketer" who continually harasses Dan with phone calls, and eventually gets Dan arrested.
• Ben (voiced by Eric Bauza) is Elise's younger brother who was mentioned in the episodes "Elise's Parents" and "The Family Camping Trip" and makes an appearance in "The Family Thanksgiving" and "The Dinosaur". He seems to show a lack of distrust in Chris and has grown fond of him.
• Mechanic Mike (voiced by Kurtwood Smith) is Dan's local mechanic who works on his car free of charge since he loves working on off-brand Filipino cars. He was in a part of a society where people build robotic armors out of car parts and battle in areas.
• Vegan Vic is the owner of the Vegan Vic store chain in "Vegetables".

Curtis Armstrong was chosen to voice the part of Dan from early production,[4] as were Dave Foley and Paget Brewster who voice Chris and Elise, respectively.

The series employs many guest stars and recurring roles. Carlos Alazraqui portrays a balloon cult member in the episode "New Mexico", both a surfer and a lifeguard in "The Beach", Maurice in "The Fancy Restaurant", Magnifico the Magnificent in "The Magician", and Flynn Goodhill in "Parents", among others. Matt Angel guest starred as a Burgerphile employee in "The Wedding". René Auberjonois is the voice of Chef Puree in "The Fancy Restaurant". Michael Gross and Meredith Baxter (of Family Ties fame) both play the voice of Elise's parents Don and Elise Sr. (respectively). Felicia Day voices the boss in his titular role "The Boss". John DiMaggio plays the voice of a police officer in three episodes, and a security guard in "baseball". Jenna Fischer voices Amber in "Anger Management". Judy Greer does the part of Jennifer in "The Neighbors". Seth Green does the voice of the mummy in his titular episode "The Mummy". Ernie Hudson played the voice of the Camp Counselor in "Summer Camp".

Other guest stars include Clancy Brown, Mark Hamill, Tom Kenny, Bill Kopp, Kevin McDonald, John C. McGinley, Daran Norris, Kurtwood Smith, Cree Summer, Harland Williams, and Henry Winkler for various parts.

On October 17, 2013, Armstrong announced on his Facebook page that the show has been canceled. His statement read:

Christian Paredes, James Jones and Larry Reaper, among others, have been kind enough to ask about Dan Vs., the animated series I've been doing for the last few seasons on The Hub. It was created by Chris Pearson and Dan Mandel and also starred Dave Foley and Paget Brewster, giving truly funny performances as Dan's best friend and wife respectively. Dan Vs. actually won an Emmy this year for direction for Dan Angel and was among my favorite past times. It has been canceled, for the baffling and inexplicable reasons that shows like Dan Vs. get canceled. I can't really explain it because it has never been explained to me. Occasionally I would ask about the status of the show and be told that it wasn't canceled, but when I would ask about specifics, there would be long, awkward pauses and then changes to other subjects, like the weather or the possibility of a government shut down (this was the previous government shutdown, which gives you an idea how long this has been going on.) Finally, I had to just give up and move on with my life. This is actually not uncommon in my business. Things just sort of fade away, with an noticeable absence of closure. You can't help dwelling on it for a time, but eventually the whole thing just becomes a sort of fragrant memory. Some fragrances, of course, are sweeter than others: I'm happy to say that in the case of Dan Vs., they are, pretty much across the board, sweet. I loved everyone I worked with, the company was great, the network was supportive and, of course, the fans were rabid and vocal in their enthusiasm. The checks cleared, it's out on DVD and it was fun and you can't really ask for more than that.[7]