Deoxyribonuclease (pyrimidine dimer)

Deoxyribonuclease (pyrimidine dimer) (EC 3.1.25.1, endodeoxyribonuclease (pyrimidine dimer), bacteriophage T4 endodeoxyribonuclease V, T4 endonuclease V) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction:

Endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate
Deoxyribonuclease (pyrimidine dimer)
Identifiers
EC no.3.1.25.1
CAS no.66143-22-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

This enzyme acts on a damaged strand, 5' from the damaged site.

References

  1. Braun AG, Radman M, Grossman L (September 1976). "Enzymatic repair of DNA: SITES OF HYDROLYSIS BY THE Escherichia coli endonuclease specific for pyrimidine dimers (correndonuclease II)". Biochemistry. 15 (18): 4116–20. doi:10.1021/bi00663a031. PMID 786366.
  2. Riazuddin S, Grossman L (September 1977). "Micrococcus luteus correndonucleases. II. Mechanism of action of two endonucleases specific for DNA containing pyrimidine dimers". The Journal of Biological Chemistry. 252 (18): 6287–93. doi:10.1016/S0021-9258(17)39953-2. PMID 330526.


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