Dibrospidium chloride

Dibrospidium chloride, also known as spirobromin, is a drug being investigated to treat bone cancer. It has potential anti-inflammatory and anti-neoplastic properties. It is an alkylating antineoplastic agent.[1][2]

Dibrospidium chloride
INN: Dibrospidium chloride
Clinical data
Other namesSpirobromin, spirobromine
ATC code
Identifiers
  • 3,12-Bis(3-bromopropanoyl)-3,6,9,12-tetraazadispiro[5.2.5~9~.2~6~]hexadecane-6,9-diium dichloride
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18-H32-Br2-N4-O2.2Cl
Molar mass567.191
3D model (JSmol)
  • [Cl-].[Cl-].BrCCC(=O)N1CC[N+]2(CC1)CC[N+]3(CCN(CC3)C(=O)CCBr)CC2
  • InChI=InChI=1S/C18H32Br2N4O2.2ClH/c19-3-1-17(25)21-5-9-23(10-6-21)13-15-24(16-14-23)11-7-22(8-12-24)18(26)2-4-20;;/h1-16H2;2*1H/q+2;;/p-2
  • Key:CURYRIVJTBNEGU-UHFFFAOYSA-L

Dibrospidium chloride and related compounds were developed in Russia in the 1980s.[3][4] It is currently used in Russia as a cytostatic antitumor chemotherapeutic drug.[5]

References
  1. Chambers M. "CAS - 86641-76-1 - CURYRIVJTBNEGU-UHFFFAOYSA-L - Dibrospidium chloride [INN]". ChemIDplus. U.S. National Library of Medicine. Retrieved 25 May 2022.
  2. "Dibrospidium Chloride". PubChem. U.S. National Library of Medicine. Retrieved 25 May 2022.
  3. Safonova TS, Chernov VA, Minakova SM, Dorokhova MI, Levkovskaya LG, Traven' NI, et al. (1983). "New antitumor agent — Spirobromin". Pharmaceutical Chemistry Journal. 17 (5): 375–377. doi:10.1007/BF00765650. S2CID 43730360.
  4. Safonova TS, Minakova SM, Chernov VA, Andreyanova TA, Deev VV (1984). "Dependence of the antitumor activity of spirobromin analogs on their structure". Pharmaceutical Chemistry Journal. 18 (12): 803–806. doi:10.1007/BF00768330. S2CID 9795933.
  5. Egorova A, Bogner E, Novoselova E, Zorn KM, Ekins S, Makarov V (February 2021). "Dispirotripiperazine-core compounds, their biological activity with a focus on broad antiviral property, and perspectives in drug design (mini-review)". European Journal of Medicinal Chemistry. 211: 113014. doi:10.1016/j.ejmech.2020.113014. PMC 7658596. PMID 33218683. S2CID 226300593.
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