Dioxotetrahydropyrimidine phosphoribosyltransferase

In enzymology, a dioxotetrahydropyrimidine phosphoribosyltransferase (EC 2.4.2.20) is an enzyme that catalyzes the chemical reaction

a 2,4-dioxotetrahydropyrimidine D-ribonucleotide + diphosphate a 2,4-dioxotetrahydropyrimidine + 5-phospho-alpha-D-ribose 1-diphosphate
dioxotetrahydropyrimidine phosphoribosyltransferase
Identifiers
EC no.2.4.2.20
CAS no.37277-75-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are 2,4-dioxotetrahydropyrimidine D-ribonucleotide and diphosphate, whereas its two products are 2,4-dioxotetrahydropyrimidine and 5-phospho-alpha-D-ribose 1-diphosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is 2,4-dioxotetrahydropyrimidine-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase. Other names in common use include dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase, dioxotetrahydropyrimidine phosphoribosyl transferase, and dioxotetrahydropyrimidine ribonucleotide pyrophosphorylase.

References

    • HATFIELD D, WYNGAARDEN JB (1964). "3-RIBOSYLPURINES. I. SYNTHESIS OF (3-RIBOSYLURIC ACID) 5'-PHOSPHATE AND (3-RIBOSYLXANTHINE) 5'-PHOSPHATE BY A PYRIMIDINE RIBONUCLEOTIDE PYROPHOSPHORYLASE OF BEEF ERYTHROCYTES". J. Biol. Chem. 239: 2580–6. PMID 14235538.


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