Dominic Kwiatkowski

Dominic Kwiatkowski FRS FMedSci FRCP[4][5] (25 May 1953 – 27 April 2023) was an English medical researcher and geneticist who was head of the parasites and microbes programme at the Wellcome Sanger Institute[3] in Cambridge and a Professor of Genomics at the University of Oxford.[4] Kwiatkowski applied genomics and computational analysis to problems in infectious disease, with the aim of finding ways to reduce the burden of disease in the developing world.[4][6][7][8]

Dominic Kwiatkowski

FRS FMedSci FRCP
Kwiatkowski in 2018
Born
Dominic P. Kwiatkowski

(1953-05-25)25 May 1953
Hammersmith, London, England
Died27 April 2023(2023-04-27) (aged 69)
Scientific career
FieldsGenomics
Malaria[1][2]
InstitutionsWellcome Sanger Institute
University of Cambridge
University of Oxford
Guy's Hospital
Leyland Motors[3]
Websitesanger.ac.uk/people/directory/kwiatkowski-dominic

Education

Kwiatkowski trained as a paediatrician at Guy's Hospital in London.[4]

Career and research

Kwiatkowski spent several years in West Africa, where malaria causes high levels of infant mortality, and this was a major focus of his research over the past thirty years.[4] He made significant contributions to the understanding of malaria pathogenesis and genetic mechanisms of resistance to the disease.[4] He also pioneered genome-wide association studies (GWAS) in Africa and led large international collaborations to characterise the genomic diversity of parasite and mosquito populations around the world.[4] This work is yielding deep insights into the evolutionary biology of drug resistance and pesticide resistance with practical implications for disease control.[4]

In 2005 Kwiatkowski founded a data-sharing network, MalariaGEN, which has fostered productive research collaborations in more than forty malaria endemic countries, and has become a model for equitable sharing of genetic data and research capacity building in resource-poor settings.[4][1]

Death

Kwiatkowski died on 27 April 2023, at the age of 69.[9]

Awards and honours

Kwiatkowski was elected a Fellow of the Royal Society (FRS) in 2018[4] and a Fellow of the Academy of Medical Sciences (FMedSci) in 2000.[10]

References
  1. Hill, Adrian V. S.; Allsopp, Catherine E. M.; Kwiatkowski, Dominic; Anstey, Nicholas M.; Twumasi, Patrick; Rowe, Pamela A.; Bennett, Stephen; Brewster, David; McMichael, Andrew J.; Greenwood, Brian M. (1991). "Common West African HLA antigens are associated with protection from severe malaria". Nature. 352 (6336): 595–600. Bibcode:1991Natur.352..595H. doi:10.1038/352595a0. ISSN 0028-0836. PMID 1865923. closed access
  2. Kwiatkowski, Dominic P. (2005). "How malaria has affected the human genome and what human genetics can teach us about malaria". American Journal of Human Genetics. 77 (2): 171–92. doi:10.1086/432519. PMC 1224522. PMID 16001361. open access
  3. "Kwiatkowski, Dominic". Sanger.ac.uk.
  4. Anon (2018). "Professor Dominic Kwiatkowski FMedSci FRS". Royalsociety.org. London: Royal Society. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
  5. "Professor Dominic Kwiatkowski - The Academy of Medical Sciences". Acmedsci.ac.uk.
  6. "Professor Dominic Kwiatkowski - Nuffield Department of Medicine". Ndm.ox.ac.uk.
  7. Dominic Kwiatkowski publications from Europe PubMed Central
  8. Robinson, T.; Campino, S. G.; Auburn, S.; Assefa, S. A.; Polley, S. D.; Manske, M.; MacInnis, B.; Rockett, K. A.; Maslen, G. L.; Sanders, M.; Quail, M. A.; Chiodini, P. L.; Kwiatkowski, D. P.; Clark, T. G.; Sutherland, C. J. (2011). "Drug-Resistant Genotypes and Multi-Clonality in Plasmodium falciparum Analysed by Direct Genome Sequencing from Peripheral Blood of Malaria Patients". PLOS ONE. 6 (8): e23204. Bibcode:2011PLoSO...623204R. doi:10.1371/journal.pone.0023204. PMC 3154926. PMID 21853089.
  9. Ferry, Georgina (16 May 2023). "Dominic Kwiatkowski obituary". The Guardian. Retrieved 16 May 2023.
  10. "Professor Dominic Kwiatkowski - The Academy of Medical Sciences". Acmedsci.ac.uk. Retrieved 5 February 2019.

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