Vincenzo Cerundolo

Vincenzo Cerundolo[3] FRS FMedSci[4][5] (20 December 1959 – 7 January 2020) was the Director of the Medical Research Council (MRC) Human Immunology Unit at the University of Oxford, at the John Radcliffe Hospital and a Professor of Immunology at the University of Oxford.[6][7] He was also a Supernumerary Fellow at Merton College, Oxford.[8] He was known for his discoveries in processing and presentation of cancer and viral peptides to T cells and lipids to invariant NKT cells. Cerundolo died of lung cancer on 7 January 2020.[9]

Vincenzo Cerundolo

FRS FMedSci
Vincenzo Cerundolo at the Royal Society admissions day in London, July 2018
Born(1959-12-20)20 December 1959
Lecce, Italy
Died7 January 2020(2020-01-07) (aged 60)[1]
EducationLiceo Scientifico De Giorgi
Alma materUniversity of Padua (MD, PhD)[2]
Scientific career
InstitutionsUniversity of Oxford
John Radcliffe Hospital
Websitewww.rdm.ox.ac.uk/people/vincenzo-cerundolo

Early life and education

Vincenzo Cerundolo was born in Lecce (Italy) on 20 December 1959 to Vittorio Cerundolo and Colomba Vissicchio. He went to school at Liceo Scientifico De Giorgi (Lecce) and then to the University of Padua to study Medicine (1979-1984). He went on to complete a higher degree at the University of Padua at the Institute of Oncology supervised by Dino Collavo and Paola Zanovello.

Career and research

After his studies at the University of Padua, Cerundolo completed his postdoctoral research with Professor Alain Townsend at the Weatherall Institute of Molecular Medicine, at the University of Oxford. He was first to demonstrate that TAP genes located within the major histocompatibility complex (MHC) transport peptides presented by MHC class I molecules and describe a novel clinical syndrome in patients with defective TAP genes. He characterised the relationship between the length of peptides and their binding affinity to MHC class I molecules, explaining the homogeneous length of peptides isolated from MHC class I molecules. He characterised the structural and kinetic mechanisms by which lipids bind to CD1 molecules and are recognized by T cells and demonstrated that harnessing CD1 restricted Natural killer T cell (NKT) cells enhances antigen specific antibody and T cell responses.

Cerundolo became Director of the MRC Human Immunology Unit in 2010.

Publications

His publications include:[7]

  • Cerundolo, V., J. Alexander, K. Anderson, C. Lamb, P. Cresswell, A. McMichael, F. Gotch, and A. Townsend. 1990. Presentation of viral antigen controlled by a gene in the major histocompatibility complex. Nature 345:449-452.
  • Moins-Teisserenc, H.T., S.D. Gadola, M. Cella, P.R. Dunbar, A. Exley, N. Blake, C. Baykal, J. Lambert, P. Bigliardi, M. Willemsen, M. Jones, S. Buechner, M. Colonna, W.L. Gross, and V. Cerundolo. 1999. Association of a syndrome resembling Wegener's granulomatosis with low surface expression of HLA class-I molecules. Lancet 354:1598-1603.
  • Cerundolo V, Elliott T, Elvin J, Bastin J, Rammensee HG, Townsend A. The binding affinity and dissociation rates of peptides for class I major histocompatibility complex molecules. 1991. Eur J Immunol, 21:2069-75.
  • Romero, P., P.R. Dunbar, D. Valmori, M. Pittet, G.S. Ogg, D. Rimoldi, J.L. Chen, D. Lienard, J.C. Cerottini, and V. Cerundolo. 1998. Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes. J Exp Med 188:1641-1650.
  • Gileadi U,  Moins-Teisserenc HT, Correa I, Booth B Jr, Dunbar PR, Sewell AK, Trowsdale J, Phillips RE, Cerundolo V.  1999. Generation of an Immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein. J Immunol, 163:6045-6052.
  • Palmowski MJ, Gileadi U, Salio M, Gallimore A, Millrain M, James E, Addey C, Scott D, Dyson J, Simpson E, Cerundolo V. 2006. Role of Immunoproteasomes in cross-presentation. J Immunol, 177: 983-990.
  • Chen, J.-L., G. Stewart-Jones, G. Bossi, M.N. Lissin, L. Wooldridge, E. Choi, G. Held, P.R. Dunbar, R. Esnouf, M. Sami, J.M. Boulter, P. Rizkallah, C. Renner, A. Sewell, P.A. van der Merwe, B.K. Jakobsen, G. Griffiths, E. Jones, and V. Cerundolo. 2005. Structural and kinetic basis for heightened immunogenicity of T-cell vaccines. J. Exp. Medicine  201:1243-1255.
  • Palmowski, M., Choi, E., Hermans, I., Gilbert, S., Chen, J-L., Gileadi, U., Salio, M., Van Pel, A., Man, S., Bonin, E., Liljestrom P., Dunbar, P.R., Cerundolo, V. 2002. Competition between cytotoxic T lymphocytes narrows the immune response induced by prime-boost vaccination protocols.  J Immunol, 168: 4391-4398.
  • Gadola, S.D., N.R. Zaccai, K. Harlos, D. Shepherd, J.C. Castro-Palomino, G. Ritter, R.R. Schmidt, E.Y. Jones, and V. Cerundolo. 2002. Structure of human CD1b with bound ligands at 2.3 Å, a maze for alkyl chains. Nature Immunol 3:721-726.
  • Koch, M., V.S. Stronge, D. Shepherd, S.D. Gadola, B. Mathew, G. Ritter, A.R. Fersht, G.S. Besra, R.R. Schmidt, E.Y. Jones, and V. Cerundolo. 2005. The crystal structure of human CD1d with and without alpha-galactosylceramide. Nature Immunol 6:819-826.
  • McCarthy, C., D. Shepherd, S. Fleire, V.S. Stronge, M. Koch, P.A. Illarionov, G. Bossi, M. Salio, G. Denkberg, F. Reddington, A. Tarlton, B.G. Reddy, R.R. Schmidt, Y. Reiter, G.M. Griffiths, P.A. van der Merwe, G.S. Besra, E.Y. Jones, F.D. Batista, and V. Cerundolo. 2007. The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation. J Exp Med 204:1131-1144.
  • Hermans, I.F., J.D. Silk, U. Gileadi, M. Salio, B. Mathew, G. Ritter, R. Schmidt, A.L. Harris, L. Old, and V. Cerundolo. 2003. NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells. J Immunol 171:5140-5147.
  • Silk, J. Hermans, I, Gileadi, U., Chong, W., Shepherd,D., Salio, M., Mathew, B., Schmidt, R.R., Lunt, S. Williams, K., Stratford, I., Harris A.,  and Cerundolo V. 2004. Utilizing the adjuvant properties of CD1d-dependent NKT cells in T cell-mediated immunotherapy.  J Clinical Investigation.  114:1800-1811.

Awards and honours

Personal life

Married in 1987, Cerundolo had one daughter and one son.

References
  1. "Professor Vincenzo Cerundolo FRS 1959-2020". University of Oxford Medical Sciences Division. Retrieved 8 January 2020.
  2. Vincenzo Cerundolo's ORCID 0000-0003-0040-3793
  3. MRC, Medical Research Council (19 August 2015). "Professor Vincenzo (Enzo) Cerundolo". mrc.ukri.org. Archived from the original on 25 June 2018. Retrieved 25 June 2018.
  4. Anon (2018). "Professor Vincenzo Cerundolo FMedSci FRS". London: Royal Society. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --"Terms, conditions and policies | Royal Society". Archived from the original on 11 November 2016. Retrieved 9 March 2016.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
  5. "Professor Vincenzo Cerundolo - The Academy of Medical Sciences". acmedsci.ac.uk.
  6. "Vincenzo Cerundolo — Radcliffe Department of Medicine". www.rdm.ox.ac.uk. Archived from the original on 25 June 2018. Retrieved 24 June 2018.
  7. Vincenzo Cerundolo publications from Europe PubMed Central
  8. "Professor Vincenzo Cerundolo". www.merton.ox.ac.uk. Archived from the original on 25 June 2018. Retrieved 25 June 2018.
  9. Immunology Leader Vincenzo Cerundolo Dies

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