EPH receptor A1

EPH receptor A1 (ephrin type-A receptor 1) is a protein that in humans is encoded by the EPHA1 gene.[5][6]

EPHA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEPHA1, Epha1, 5730453L17Rik, AL033318, Eph, Esk, EPHT, EPHT1, EPH receptor A1, EPH
External IDsOMIM: 179610 MGI: 107381 HomoloGene: 3835 GeneCards: EPHA1
Orthologs
SpeciesHumanMouse
Entrez

2041

13835

Ensembl

ENSG00000146904
ENSG00000284816

ENSMUSG00000029859

UniProt

P21709

Q60750

RefSeq (mRNA)

NM_005232

NM_023580

RefSeq (protein)

NP_005223

NP_076069

Location (UCSC)Chr 7: 143.39 – 143.41 MbChr 6: 42.34 – 42.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.[6]

References

  1. ENSG00000284816 GRCh38: Ensembl release 89: ENSG00000146904, ENSG00000284816 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029859 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ephnomenclaturecommittee (Sep 1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. S2CID 26773768.
  6. "Entrez Gene: EPHA1 EPH receptor A1".

Further reading


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