Endothall

Endothall (3,6-endoxohexahydrophthalic acid) is used as an herbicide for terrestrial and aquatic plants. It is used as an aquatic herbicide for submerged aquatic plants and algae in lakes, ponds and irrigation canals.[2] It is used as a desiccant on potatoes, hops, cotton, clover and alfalfa. It is used as a biocide to control mollusks and algae in cooling towers.

Endothall
Names
IUPAC name
7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
Other names
Endothal; 3,6-Endoxohexahydrophthalic acid
Identifiers
3D model (JSmol)
ECHA InfoCard 100.005.146
UNII
  • InChI=1S/C8H10O5/c9-7(10)5-3-1-2-4(13-3)6(5)8(11)12/h3-6H,1-2H2,(H,9,10)(H,11,12)
    Key: GXEKYRXVRROBEV-UHFFFAOYSA-N
  • C1CC2C(C(C1O2)C(=O)O)C(=O)O
Properties
C8H10O5
Molar mass 186.163 g·mol−1
Density 1.431 g/cm3 (20 °C)[1]
Melting point 144 °C (291 °F; 417 K)[1]
100 g/L (20 °C)[1]
Hazards
Lethal dose or concentration (LD, LC):
38 mg/kg (oral, rat)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

The chemical formula for endothall is C8H10O5. Its Chemical Abstracts Service (CAS) name is 7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid. Its is an organic acid but is used as the dipotassium salt or the mono-N,N-dimethylalkylamine salt.[3] It is considered safe in drinking water by the EPA up to a maximum contaminant level of 0.1 mg/L (100 ppb). Some people who drink water contaminated above this level for many years experience stomach or intestine problems.[4]

Endothall is chemically related to cantharidin.[5] Both compounds are protein phosphatase 2A inhibitors.[6]

See also

References
  1. Record in the GESTIS Substance Database of the Institute for Occupational Safety and Health
  2. "Herbicides against Hydrilla". Tompkins County NY website.
  3. "Reregistration Eligibility Decision for Endothall" (PDF). EPA. Archived from the original (PDF) on 16 October 2014. Retrieved 16 July 2012.
  4. "Basic Information about Endothall in Drinking Water". EPA. Retrieved 16 July 2012.
  5. Li, YM; Casida, JE (15 December 1992). "Cantharidin-binding protein: identification as protein phosphatase 2A". Proceedings of the National Academy of Sciences of the United States of America. 89 (24): 11867–70. Bibcode:1992PNAS...8911867L. doi:10.1073/pnas.89.24.11867. PMC 50658. PMID 1334551.
  6. Liu, Ji-Yuan; Chen, Xi-En; Zhang, Ya-Lin (20 July 2015). "Insights into the key interactions between human protein phosphatase 5 and cantharidin using molecular dynamics and site-directed mutagenesis bioassays". Scientific Reports. 5 (1): 12359. Bibcode:2015NatSR...512359L. doi:10.1038/srep12359. PMC 4507179. PMID 26190207.
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