Amino acid neurotransmitter

An amino acid neurotransmitter is an amino acid which is able to transmit a nerve message across a synapse. Neurotransmitters (chemicals) are packaged into vesicles that cluster beneath the axon terminal membrane on the presynaptic side of a synapse in a process called endocytosis.[1]

Activity at an axon terminal: Neuron A is transmitting a signal at the axon terminal to neuron B (receiving). Features: 1. Mitochondrion. 2. synaptic vesicle with neurotransmitters. 3. Autoreceptor. 4. Synapse with neurotransmitter released (serotonin). 5. Postsynaptic receptors activated by neurotransmitter (induction of a postsynaptic potential). 6. Calcium channel. 7. Exocytosis of a vesicle. 8. Recaptured neurotransmitter.

Amino acid neurotransmitter release (exocytosis) is dependent upon calcium Ca2+ and is a presynaptic response.

Types

Excitatory amino acids (EAA) will activate post-synaptic cells.[2] inhibitory amino acids (IAA) depress the activity of post-synaptic cells.[2]

Amino acid[3][4] Excitatory or inhibitory
Aspartic acid Excitatory
β-alanine Inhibitory
Cysteine Excitatory
GABA (adult human brain) Inhibitory (adult); excitatory (developing)
Glycine Inhibitory
Glutamic acid Excitatory
Homocysteine Excitatory
Taurine Inhibitory

See also

References
  1. "Axon Terminal : on Medical Dictionary Online". Archived from the original on 14 January 2009. Retrieved 2008-12-25.
  2. D'haenen, Hugo; den Boer, Johan A. (2002). Biological Psychiatry (digitised online by Google books). Paul Willner. John Wiley and Sons. p. 415. ISBN 978-0-471-49198-9. Retrieved 2008-12-26.
  3. Dalangin, R; Kim, A; Campbell, RE (27 August 2020). "The Role of Amino Acids in Neurotransmission and Fluorescent Tools for Their Detection". International Journal of Molecular Sciences. 21 (17): 6197. doi:10.3390/ijms21176197. PMC 7503967. PMID 32867295.
  4. Foye, William O.; Lemke, Thomas L. (2007). Foye's Principles of Medicinal Chemistry. David A. Williams. Lippincott Williams & Wilkins. p. 446. ISBN 978-0-7817-6879-5.
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