Exonuclease VII
The enzyme exodeoxyribonuclease VII (EC 3.1.11.6, Escherichia coli exonuclease VII, E. coli exonuclease VII, endodeoxyribonuclease VII, exodeoxyribonuclease VII) is a bacterial exonuclease enzyme.[1][2] It is composed of two nonidentical subunits; one large subunit and 4 small ones.[3] that catalyses exonucleolytic cleavage in either 5′- to 3′- or 3′- to 5′-direction to yield nucleoside 5′-phosphates. The large subunit also contains an N-terminal OB-fold domain that binds to nucleic acids.
| Exonuclease VII, large subunit | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Exonuc_VII_L | ||||||||
| Pfam | PF02601 | ||||||||
| InterPro | IPR020579 | ||||||||
| |||||||||
| Exonuclease VII small subunit | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of exodeoxyribonuclease vii small subunit (np_881400.1) from bordetella pertussis at 2.40 a resolution | |||||||||
| Identifiers | |||||||||
| Symbol | Exonuc_VII_S | ||||||||
| Pfam | PF02609 | ||||||||
| InterPro | IPR003761 | ||||||||
| |||||||||
References
- Chase, J.W.; Richardson, C.C. (1974). "Ribonuclease VII of Escherichia coli". J. Biol. Chem. 249 (14): 4545–4552. PMID 4602029.
- Chase, J.W.; Richardson, C.C. (1974). "Exonuclease VII of Escherichia coli". J. Biol. Chem. 249 (14): 4553–4561. PMID 4602030.
- Vales LD, Rabin BA, Chase JW (August 1982). "Subunit structure of Escherichia coli exonuclease VII". J. Biol. Chem. 257 (15): 8799–805. PMID 6284744.
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