Fcα/μR
Fcα/μR, also known as is CD351 (Cluster of Differentiation 351), is an Fc receptor that binds IgM with high affinity and IgA with a 10-fold lower affinity.[1] In mice the receptor is expressed on macrophages, follicular dendritic cells, marginal zone B cells, follicular B cells, and kidney tubular epithelial cells. In humans expression has been described on intestinal lamina propria cells, Paneth cells, follicular dendritic cells in tonsils, activated macrophages and some types of pre-germinal centre IgD+/CD38+ B cells.
| Fc receptor, IgA, IgM, high affinity | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | FCAMR, CD351 | ||||||
| NCBI gene | 83953 | ||||||
| HGNC | 24692 | ||||||
| OMIM | 605484 | ||||||
| RefSeq | NM_032029 | ||||||
| UniProt | Q96SA2 | ||||||
| Other data | |||||||
| Locus | Chr. 1 q32.1 | ||||||
| |||||||
References
- Yang X, Zhao Q, Zhu L, Zhang W (May 2013). "The three complementarity-determining region-like loops in the second extracellular domain of human Fc alpha/mu receptor contribute to its binding of IgA and IgM". Immunobiology. 218 (5): 798–809. doi:10.1016/j.imbio.2012.09.004. PMID 23182711.
External links
- Poly-Ig+Receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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