Glycolipid 2-alpha-mannosyltransferase
In enzymology, a glycolipid 2-alpha-mannosyltransferase (EC 2.4.1.131) is an enzyme that catalyzes the chemical reaction in which an alpha-D-mannosyl residue is transferred from GDP-mannose to lipid-linked oligosaccharide, being attached by an alpha-1,2-D-mannosyl-D-mannose bond.
| glycolipid 2-alpha-mannosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.131 | ||||||||
| CAS no. | 74506-43-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase. Other names in common use include guanosine diphosphomannose-oligosaccharide-lipid, mannosyltransferase, GDP-mannose-oligosaccharide-lipid mannosyltransferase, and oligosaccharide-lipid mannosyltransferase.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1S4N, 1S4O, and 1S4P.
References
- Schutzbach JS, Springfield JD, Jensen JW (1980). "The biosynthesis of oligosaccharide-lipids. Formation of an alpha-1,2-mannosyl-mannose linkage". J. Biol. Chem. 255 (9): 4170–5. PMID 6154707.