Glycoprotein IX

Glycoprotein IX (platelet) (GP9) also known as CD42a (Cluster of Differentiation 42a), is a human gene.[5]

GP9
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGP9, CD42a, GPIX, Glycoprotein IX, glycoprotein IX platelet
External IDsOMIM: 173515 MGI: 1860137 HomoloGene: 144 GeneCards: GP9
Orthologs
SpeciesHumanMouse
Entrez

2815

54368

Ensembl

ENSG00000169704

ENSMUSG00000030054

UniProt

P14770

O88186

RefSeq (mRNA)

NM_000174

NM_018762

RefSeq (protein)

NP_000165

NP_061232

Location (UCSC)Chr 3: 129.06 – 129.06 MbChr 6: 87.76 – 87.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Platelet glycoprotein IX (GP9) is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib (GP Ib), a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor (VWF; MIM 193400) (known as the Glycoprotein Ib-IX-V Receptor Complex). The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with GP9 and platelet glycoprotein V (GP5; MIM 173511).[supplied by OMIM][5]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000169704 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030054 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: GP9 glycoprotein IX (platelet)".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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