Glycolipid 2-alpha-mannosyltransferase

In enzymology, a glycolipid 2-alpha-mannosyltransferase (EC 2.4.1.131) is an enzyme that catalyzes the chemical reaction in which an alpha-D-mannosyl residue is transferred from GDP-mannose to lipid-linked oligosaccharide, being attached by an alpha-1,2-D-mannosyl-D-mannose bond.

glycolipid 2-alpha-mannosyltransferase
Identifiers
EC no.2.4.1.131
CAS no.74506-43-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase. Other names in common use include guanosine diphosphomannose-oligosaccharide-lipid, mannosyltransferase, GDP-mannose-oligosaccharide-lipid mannosyltransferase, and oligosaccharide-lipid mannosyltransferase.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1S4N, 1S4O, and 1S4P.

References

    • Schutzbach JS, Springfield JD, Jensen JW (1980). "The biosynthesis of oligosaccharide-lipids. Formation of an alpha-1,2-mannosyl-mannose linkage". J. Biol. Chem. 255 (9): 4170–5. PMID 6154707.


    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.