Glycosaminoglycan galactosyltransferase

In enzymology, a glycosaminoglycan galactosyltransferase (EC 2.4.1.74) is an enzyme that catalyzes the chemical reaction

UDP-galactose + glycosaminoglycan UDP + D-galactosylglycosaminoglycan
glycosaminoglycan galactosyltransferase
Identifiers
EC no.2.4.1.74
CAS no.51004-28-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are UDP-galactose and glycosaminoglycan, whereas its two products are UDP and D-galactosylglycosaminoglycan.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:glycosaminoglycan D-galactosyltransferase. This enzyme is also called uridine diphosphogalactose-mucopolysaccharide galactosyltransferase.

References

    • Sussman M, Osborn MJ (1964). "UDP-glucose polysaccharide transferase in the cellular slime mold Dictyostelium discoideum: appearance and disappearance of activity during cell differentiation". Proc. Natl. Acad. Sci. USA. 52 (1): 81–87. Bibcode:1964PNAS...52...81S. doi:10.1073/pnas.52.1.81. PMC 300577. PMID 14192661.


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