HLA-DQ4

HLA-DQ4 (DQ4) is a serotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the antibody recognition of β4 subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ4 are encoded by the HLA-DQB1*04 allele group. This group currently contains 2 common alleles, DQB1*0401 and DQB1*0402. HLA-DQ4 and HLA-DQB1*04 are almost synonymous in meaning. DQ4 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. These isoforms, nicknamed DQ4.3 and DQ4.4, are also encoded by the DQA1*0303 and DQA1*0401 genes, respectively.

HLA-DQ4
Illustration of HLA-DQ with gliadin peptide in the binding pocket.
Polymer typeMHC Class II, DQ cell surface antigen
Cis-haplotype Haplotype
isoform subtype DQA1 DQB1
DQ α3β4.1 DQ4.3a *0303 *0401
DQ α3β4.2 DQ4.3b *0303 *0402
DQ α4β4.2 DQ4.2 *0401 *0402

Serotype
DQB1*04 serotyping[1]
DQB1*DQ4DQ3 Sample
allele % %size (N)
*04017110176
*04028621085
Red indicates the level of 'false' reaction in non-DQ4 serotypes

Alleles

Haplotypes

DQ4.3

DQA1*0303:DQB1*0401 is linked to DRB1*0405 and is common on the west Pacific rim, from Indonesia to Japan and inland areas of Eastern Asia. In Japan it confers susceptibility to juvenile diabetes likely via the DR4 gene.

DQA1*0303:DQB1*0402 is primarily found in Northeastern Asia and the west Pacific rim. It is similar to DQA1*0303:DQB1*0402.

DQ4.2

DQA1*0401:DQB1*0402 has a trimodal global distribution. The highest frequencies are found in the highland regions of the new world, peaking in NW Mexico and in the Andes. It is also found at high levels in Namibia and Botswana. Between these two population it is moderately high in the Ainu of northern Japan.

DQ4 and Disease

DQ4 is associated with:

  • juvenile diabetic retinopathy [2][3]

The DR8-DQ4 haplotype is associated with

DR4-DQ4(DRB1*0405:DQB1*0401) is associated with:

The DQA1*0303:DQB1*04 haplotype is associated with:

Other diseases mentioned are high-altitude pulmonary edema, Vogt–Koyanagi–Harada disease (DRB1*0405, see above table for Japanese), HIV resistance in the US, and haemophilia A (anti-FVIII inhibitor response).

DQ4 distribution
20 of the most common DR-DQ haplotypes in Japanese
DQ DR-DQ DR DQ Freq
Serotype haplotype B1 A1 B1 %[14] rank
DQ4 DR4-DQ4040503030401 14. 3 ²
041003030402 1. 9 11
DR8-DQ4080204010402 1. 3 15
DQ5 DR1-DQ5010101010501 6. 4 5
DR14-DQ5140101040502 1. 1 17
140101040503 0. 8 18
140501040503 1. 6 13
DQ6 DR8-DQ6 080301030601 9. 3 4
DR13-DQ6 130201020604 6. 0 6
DR15-DQ6 150201030601 12. 9 ³
150101020602 6. 0 7
DQ7 DR11-DQ7 110105050301 1. 8 12
DR12-DQ7 120105050301 2. 7 9
120206010301 1. 3 15
DR14-DQ7 140305030301 1. 4 14
DQ8 DR4-DQ8 040303010302 1. 9 10
040603010302 3. 4 8
DR8-DQ8 080204010302 0. 7 19
DQ9 DR9-DQ9090103020303 16. 0 1

The table to the left shows the values of Japanese[14](values converted from phenotype frequencies to haplotype frequencies for sake of consistency) DR-DQ types. This table is presented here because of the diversity of DQ4 types in the Japanese population not seen elsewhere. DQ4 is typically rare most of the world but where it appears more frequently is something of interest. The node of DQ4 is with the DQA1*0401:DQB1*0402 (DQ4.24 for this page) haplotype in Northwestern Mexico and the highland region of western South America reaching 40% haplotype frequencies in that area. Outside of the Indigenous American population DQ4.24 is elevated at 10% in the Ainu of Hokkaidō, Japan. There are a number of other A-B haplotypes that suggest a connection between the Ainu and the Meso-American and Andean populations as well as Lakota Sioux all have DQ4 levels higher than the Ainu. The linkage of DQ4 in Asia appears to be heaviest with DR8 (DR*0801, DR*0802, DR*0804) for DQ4.24 and the frequency is elevated from the Ryukyu Islands to Okhotsk, Ulchi, Negidal, Tofalar at approximately 10% falling off in the Mansi at 4% and punctate levels in between. Haplotype diversity of DQB1*0402 appears to be centered around the Amur River/Japanese Island Chain, and diversity of DQB1*0401 very roughly follows a similar pattern. DQ4.24 is also high in the Swedes however this may be due to east to west gene flow traceable at other HLA loci.

Since DQA1*0401:DQB1*0402 is found in the !Kung, one reasonably assumes it evolved in Africa and migrated with one of several potential waves, probably the earliest. Tracing the migration route is excessively difficult, but it appears that a possible second node of expansion in Central Asia and not the West Pacific Rim/Austro-Indic route postulated as the early human distribution. The most common haplotypes in the !Kung (for example Cw-B) that also appear in Eurasia appear to have been associated with the earliest migration, and is suggestive of a coastal migration; however the relatively high frequencies in the Ainu[15] and Amur basin[16] suggest a migration through the Transbaikal that is consistent with archaeology from about 18 kya. One expects with such a route that Korean would be higher than Japanese and Japanese higher the Ryukyuans still higher than Taiwan aboriginals. From the west gene frequencies in the Levant and Black Sea region are at 'diffusive' levels whereas there are pockets of increased frequency in the Zoroastrians of Yadz region (DQA1*0401 and DQB1*0402). Thus the DR8-DQ4.24 haplotype is probably one of western origin.

The DR4-DQA1*0303:DQB1*040X can be found at high frequencies in PNG highland groups [17] but not DQ4.24. The DR*0405 and DR*410 are found specifically associated with these DQ types and there is some haplotype diversity. So that it appears the presence of the DQA1*03:DQB1*04 is of West Pacific Rim origins in Japanese and proximal Siberians, but unfortunately there is no current typing of these haplotypes in the Taiwan aboriginal population. The presence in Indonesia may be the result of retrograde gene flow that can be established by other HLA types as well as mtDNA.

References
  1. derived from IMGT/HLA
  2. Mimura T, Funatsu H, Uchigata Y, Kitano S, Noma H, Shimizu E, Konno Y, Amano S, Araie M, Yoshino O, Iwamoto Y, Hori S (2003). "Relationship between human leukocyte antigen status and proliferative diabetic retinopathy in patients with younger-onset type 1 diabetes mellitus". Am J Ophthalmol. 135 (6): 844–8. doi:10.1016/S0002-9394(02)02291-2. PMID 12788125.
  3. Mimura T, Funatsu H, Uchigata Y, Kitano S, Shimizu E, Amano S, Yamagami S, Noma H, Araie M, Hori S (2005). "Glutamic acid decarboxylase autoantibody prevalence and association with HLA genotype in patients with younger-onset type 1 diabetes and proliferative diabetic retinopathy". Ophthalmology. 112 (11): 1904–9. doi:10.1016/j.ophtha.2005.05.016. PMID 16157380.
  4. Porto T, Coelho I, Boavida J, Pereira C, Nunes J, Mendonça D, Martins B, Sobrinho L, Leite V (2006). "Association of HLA DQ4-DR8 haplotype with papillary thyroid carcinomas". Clin Endocrinol. 64 (2): 179–83. doi:10.1111/j.1365-2265.2006.02445.x. PMID 16430717. S2CID 22695710.
  5. Smerdel A, Lie B, Finholt C, Ploski R, Førre Ø, Undlien D, Thorsby E (2003). "An additional susceptibility gene for juvenile idiopathic arthritis in the HLA class I region on several DR-DQ haplotypes". Tissue Antigens. 61 (1): 80–4. doi:10.1034/j.1399-0039.2003.610107.x. PMID 12622778.
  6. Smerdel A, Ploski R, Flatø B, Musiej-Nowakowska E, Thorsby E, Førre Ø (2002). "Juvenile idiopathic arthritis (JIA) is primarily associated with HLA-DR8 but not DQ4 on the DR8-DQ4 haplotype". Ann Rheum Dis. 61 (4): 354–7. doi:10.1136/ard.61.4.354. PMC 1754045. PMID 11874841.
  7. Betsou F, Borrego M, Guillaume N, Catry M, Romão S, Machado-Caetano J, Sueur J, Mention J, Faille N, Orfila J (2003). "Cross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factor". Clin Diagn Lab Immunol. 10 (3): 446–50. doi:10.1128/CDLI.10.3.446-450.2003. PMC 154954. PMID 12738647.
  8. Birol A, Anadolu R, Tutkak H, Gürgey E (2002). "HLA-class 1 and class 2 antigens in Turkish patients with pemphigus". Int J Dermatol. 41 (2): 79–83. doi:10.1046/j.1365-4362.2002.01370.x. PMID 11982641. S2CID 26468899.
  9. Kawa S, Ota M, Yoshizawa K, Horiuchi A, Hamano H, Ochi Y, Nakayama K, Tokutake Y, Katsuyama Y, Saito S, Hasebe O, Kiyosawa K (2002). "HLA DRB10405-DQB10401 haplotype is associated with autoimmune pancreatitis in the Japanese population". Gastroenterology. 122 (5): 1264–9. doi:10.1053/gast.2002.33022. PMID 11984513.
  10. Kikuoka N, Sugihara S, Yanagawa T, Ikezaki A, Kim H, Matsuoka H, Kobayashi Y, Wataki K, Konda S, Sato H, Miyamoto S, Sasaki N, Sakamaki T, Niimi H, Murata M (2001). "Cytotoxic T lymphocyte antigen 4 gene polymorphism confers susceptibility to type 1 diabetes in Japanese children: analysis of association with HLA genotypes and autoantibodies". Clin Endocrinol. 55 (5): 597–603. doi:10.1046/j.1365-2265.2001.01397.x. PMID 11894970. S2CID 39528979.
  11. Tsuchiya K, Kimura A, Kondo M, Nishimura Y, Sasazuki T (2001). "Combination of HLA-A and HLA class II alleles controls the susceptibility to rheumatoid arthritis". Tissue Antigens. 58 (6): 395–401. doi:10.1034/j.1399-0039.2001.580608.x. PMID 11929590.
  12. Matake H, Okabe N, Naito S, Yao T (1992). "An HLA study on 149 Japanese patients with Crohn's disease". Gastroenterol Jpn. 27 (4): 496–501. doi:10.1007/BF02777785. PMID 1526431. S2CID 24096011.
  13. Nakajima A, Matsuhashi N, Kodama T, Yazaki Y, Takazoe M, Kimura A (1995). "HLA-linked susceptibility and resistance genes in Crohn's disease". Gastroenterology. 109 (5): 1462–7. doi:10.1016/0016-5085(95)90631-2. PMID 7557126.
  14. Tanaka T, Ohmori M, Yasunaga S, Ohshima K, Kikuchi M, Sasazuki T (1999). "DNA typing of HLA class II genes (HLA-DR, -DQ and -DP) in Japanese patients with histiocytic necrotizing lymphadenitis (Kikuchi's disease)". Tissue Antigens. 54 (3): 246–253. doi:10.1034/j.1399-0039.1999.540305.x. PMID 10519361.
  15. Bannai M, Tokunaga K, Imanishi T, Harihara S, Fujisawa K, Juji T, Omoto K (1996). "HLA class II alleles in Ainu living in Hidaka District, Hokkaidō, northern Japan". Am J Phys Anthropol. 101 (1): 1–9. doi:10.1002/(SICI)1096-8644(199609)101:1<1::AID-AJPA1>3.0.CO;2-Z. PMID 8876810.
  16. Uinuk-Ool TS, Takezaki N, Sukernik RI, Nagl S, Klein J (2002). "Origin and affinities of indigenous Siberian populations as revealed by HLA class II gene frequencies". Human Genetics. 110 (3): 209–226. doi:10.1007/s00439-001-0668-0. PMID 11935333. S2CID 20940785.
  17. Gao X, Bhatia K, Trent RJ, Serjeantson SW (1992). "HLA-DR, DQ nucleotide sequence polymorphisms in five Melanesian populations". Tissue Antigens. 40 (1): 31–37. doi:10.1111/j.1399-0039.1992.tb01954.x. PMID 1440559.
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