Hemoglobin subunit zeta

Hemoglobin subunit zeta is a protein that in humans is encoded by the HBZ gene.[5][6]

HBZ
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHBZ, HBZ-T1, HBZ1, hemoglobin subunit zeta, HBAZ
External IDsOMIM: 142310 MGI: 96019 HomoloGene: 110705 GeneCards: HBZ
Orthologs
SpeciesHumanMouse
Entrez

3050

15126

Ensembl

ENSG00000130656

ENSMUSG00000055609

UniProt

P02008

P06467

RefSeq (mRNA)

NM_005332

NM_010405

RefSeq (protein)

NP_005323

NP_034535

Location (UCSC)Chr 16: 0.14 – 0.15 MbChr 11: 32.23 – 32.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta1 - 3'.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000130656 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000055609 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (April 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.
  6. "Entrez Gene: HBZ hemoglobin, zeta".

Further reading


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