Poliovirus receptor-related 2

Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), is a human plasma membrane glycoprotein.[5]

NECTIN2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNECTIN2, CD112, HVEB, PRR2, PVRR2, PVRL2, nectin cell adhesion molecule 2
External IDsOMIM: 600798 MGI: 97822 HomoloGene: 86092 GeneCards: NECTIN2
Orthologs
SpeciesHumanMouse
Entrez

5819

19294

Ensembl

ENSG00000130202

ENSMUSG00000062300

UniProt

Q92692

P32507

RefSeq (mRNA)

NM_001042724
NM_002856

NM_001159724
NM_008990

RefSeq (protein)

NP_001036189
NP_002847

NP_001153196
NP_033016

Location (UCSC)Chr 19: 44.85 – 44.89 MbChr 7: 19.45 – 19.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[5]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000130202 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000062300 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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