Interleukin 10 receptor, beta subunit

Interleukin 10 receptor, beta subunit is a subunit for the interleukin-10 receptor. IL10RB is its human gene.[5]

IL10RB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL10RB, CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2, Interleukin 10 receptor, beta subunit, interleukin 10 receptor subunit beta
External IDsOMIM: 123889 MGI: 109380 HomoloGene: 523 GeneCards: IL10RB
Orthologs
SpeciesHumanMouse
Entrez

3588

16155

Ensembl

ENSG00000243646

ENSMUSG00000022969

UniProt

Q08334

Q61190

RefSeq (mRNA)

NM_000628

NM_008349

RefSeq (protein)

NP_000619

n/a

Location (UCSC)Chr 21: 33.27 – 33.31 MbChr 16: 91.2 – 91.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

IL10RB has also been designated CDw210b (cluster of differentiation w210b).

The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFNAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000243646 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022969 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: IL10RB interleukin 10 receptor, beta".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.