Interleukin 1 receptor, type II

Interleukin 1 receptor, type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its human gene.

IL1R2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL1R2, CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB, Interleukin 1 receptor, type II, interleukin 1 receptor type 2
External IDsOMIM: 147811 MGI: 96546 HomoloGene: 7783 GeneCards: IL1R2
Orthologs
SpeciesHumanMouse
Entrez

7850

16178

Ensembl

ENSG00000115590

ENSMUSG00000026073

UniProt

P27930

P27931

RefSeq (mRNA)

NM_001261419
NM_004633
NM_173343

NM_010555
NM_001360800
NM_001360801

RefSeq (protein)

NP_001248348
NP_004624

NP_034685
NP_001347729
NP_001347730

Location (UCSC)Chr 2: 101.99 – 102.03 MbChr 1: 40.11 – 40.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a decoy receptor for certain cytokines that belongs to the interleukin-1 receptor family. This protein binds interleukin-1α (IL1A), interleukin-1β (IL1B), and interleukin 1 receptor antagonist (IL1Ra), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling. IL-1R2 protein also interacts non-productively with the second component of the signaling IL-1 receptor, namely IL-1RAcP,[5] and a complex of the IL-1R2 and IL-1RAcP extracellular domains with interleukin-1 beta has been solved by X-ray crystallography.[6] Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000115590 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026073 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lang, D; Knop, J; Wesche, H; Raffetseder, U; Kurrie, R; Boraschi, D; Martin, MU (1998). "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness". Journal of Immunology. 161 (12): 6871–6877. doi:10.4049/jimmunol.161.12.6871. PMID 9862719. S2CID 8940186.
  6. Wang, Dongli; Zhang, Senyan; Li, Liang; Liu, Xi; Mei, Kunrong; Wang, Xinquan (29 August 2010). "Structural insights into the assembly and activation of IL-1β with its receptors". Nature Immunology. 11 (10): 905–911. doi:10.1038/ni.1925. PMID 20802483. S2CID 20315956.
  7. "Entrez Gene: IL1R2 interleukin 1 receptor, type II".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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