Interleukin 1 receptor, type II
Interleukin 1 receptor, type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its human gene.
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| Aliases | IL1R2, CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB, Interleukin 1 receptor, type II, interleukin 1 receptor type 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 147811 MGI: 96546 HomoloGene: 7783 GeneCards: IL1R2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
The protein encoded by this gene is a decoy receptor for certain cytokines that belongs to the interleukin-1 receptor family. This protein binds interleukin-1α (IL1A), interleukin-1β (IL1B), and interleukin 1 receptor antagonist (IL1Ra), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling. IL-1R2 protein also interacts non-productively with the second component of the signaling IL-1 receptor, namely IL-1RAcP,[5] and a complex of the IL-1R2 and IL-1RAcP extracellular domains with interleukin-1 beta has been solved by X-ray crystallography.[6] Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.[7]
References
- GRCh38: Ensembl release 89: ENSG00000115590 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000026073 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Lang, D; Knop, J; Wesche, H; Raffetseder, U; Kurrie, R; Boraschi, D; Martin, MU (1998). "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness". Journal of Immunology. 161 (12): 6871–6877. doi:10.4049/jimmunol.161.12.6871. PMID 9862719. S2CID 8940186.
- Wang, Dongli; Zhang, Senyan; Li, Liang; Liu, Xi; Mei, Kunrong; Wang, Xinquan (29 August 2010). "Structural insights into the assembly and activation of IL-1β with its receptors". Nature Immunology. 11 (10): 905–911. doi:10.1038/ni.1925. PMID 20802483. S2CID 20315956.
- "Entrez Gene: IL1R2 interleukin 1 receptor, type II".
Further reading
- McMahan CJ, Slack JL, Mosley B, Cosman D, Lupton SD, Brunton LL, Grubin CE, Wignall JM, Jenkins NA, Brannan CI (Oct 1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types". The EMBO Journal. 10 (10): 2821–32. doi:10.1002/j.1460-2075.1991.tb07831.x. PMC 452992. PMID 1833184.
- Dripps DJ, Verderber E, Ng RK, Thompson RC, Eisenberg SP (Oct 1991). "Interleukin-1 receptor antagonist binds to the type II interleukin-1 receptor on B cells and neutrophils". The Journal of Biological Chemistry. 266 (30): 20311–5. doi:10.1016/S0021-9258(18)54924-3. PMID 1834644.
- Fasano MB, Cousart S, Neal S, McCall CE (Nov 1991). "Increased expression of the interleukin 1 receptor on blood neutrophils of humans with the sepsis syndrome". The Journal of Clinical Investigation. 88 (5): 1452–9. doi:10.1172/JCI115454. PMC 295647. PMID 1834697.
- Sadouk MB, Pelletier JP, Tardif G, Kiansa K, Cloutier JM, Martel-Pelletier J (Sep 1995). "Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor". Laboratory Investigation. 73 (3): 347–55. PMID 7564267.
- Symons JA, Young PR, Duff GW (Feb 1995). "Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist". Proceedings of the National Academy of Sciences of the United States of America. 92 (5): 1714–8. Bibcode:1995PNAS...92.1714S. doi:10.1073/pnas.92.5.1714. PMC 42590. PMID 7878046.
- Arend WP, Malyak M, Smith MF, Whisenand TD, Slack JL, Sims JE, Giri JG, Dower SK (Nov 1994). "Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids". Journal of Immunology. 153 (10): 4766–74. doi:10.4049/jimmunol.153.10.4766. PMID 7963543. S2CID 23226920.
- Giri JG, Wells J, Dower SK, McCall CE, Guzman RN, Slack J, Bird TA, Shanebeck K, Grabstein KH, Sims JE (Dec 1994). "Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses". Journal of Immunology. 153 (12): 5802–9. doi:10.4049/jimmunol.153.12.5802. PMID 7989776. S2CID 20750506.
- Re F, Muzio M, De Rossi M, Polentarutti N, Giri JG, Mantovani A, Colotta F (Feb 1994). "The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor". The Journal of Experimental Medicine. 179 (2): 739–43. doi:10.1084/jem.179.2.739. PMC 2191363. PMID 8294881.
- Colotta F, Re F, Muzio M, Bertini R, Polentarutti N, Sironi M, Giri JG, Dower SK, Sims JE, Mantovani A (Jul 1993). "Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4". Science. 261 (5120): 472–5. Bibcode:1993Sci...261..472C. doi:10.1126/science.8332913. PMID 8332913.
- Sambo P, Fadlon EJ, Sironi M, Matteucci C, Introna M, Mantovani A, Colotta F (Mar 1996). "Reactive oxygen intermediates cause rapid release of the interleukin-1 decoy receptor from human myelomonocytic cells". Blood. 87 (5): 1682–6. doi:10.1182/blood.V87.5.1682.bloodjournal8751682. PMID 8634411.
- Larregina A, Morelli A, Kolkowski E, Fainboim L (Feb 1996). "Flow cytometric analysis of cytokine receptors on human Langerhans' cells. Changes observed after short-term culture". Immunology. 87 (2): 317–25. doi:10.1046/j.1365-2567.1996.451513.x. PMC 1384291. PMID 8698397.
- Liu C, Hart RP, Liu XJ, Clevenger W, Maki RA, De Souza EB (Aug 1996). "Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA". The Journal of Biological Chemistry. 271 (34): 20965–72. doi:10.1074/jbc.271.34.20965. PMID 8702856.
- Colotta F, Saccani S, Giri JG, Dower SK, Sims JE, Introna M, Mantovani A (Apr 1996). "Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes". Journal of Immunology. 156 (7): 2534–41. doi:10.4049/jimmunol.156.7.2534. PMID 8786316. S2CID 7669945.
- Sébire G, Delfraissy JF, Demotes-Mainard J, Oteifeh A, Emilie D, Tardieu M (Aug 1996). "Interleukin-13 and interleukin-4 act as interleukin-6 inducers in human microglial cells". Cytokine. 8 (8): 636–41. doi:10.1006/cyto.1996.0085. PMID 8894439.
- Lovenberg TW, Crowe PD, Liu C, Chalmers DT, Liu XJ, Liaw C, Clevenger W, Oltersdorf T, De Souza EB, Maki RA (Nov 1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". Journal of Neuroimmunology. 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719. S2CID 53171191.
- van der Poll T, de Waal Malefyt R, Coyle SM, Lowry SF (Jan 1997). "Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13". The Journal of Infectious Diseases. 175 (1): 118–22. doi:10.1093/infdis/175.1.118. PMID 8985204.
- Rauschmayr T, Groves RW, Kupper TS (May 1997). "Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1-mediated inflammation". Proceedings of the National Academy of Sciences of the United States of America. 94 (11): 5814–9. Bibcode:1997PNAS...94.5814R. doi:10.1073/pnas.94.11.5814. PMC 20863. PMID 9159157.
- Gomez E, Morel G, Cavalier A, Liénard MO, Haour F, Courtens JL, Jégou B (Jun 1997). "Type I and type II interleukin-1 receptor expression in rat, mouse, and human testes". Biology of Reproduction. 56 (6): 1513–26. doi:10.1095/biolreprod56.6.1513. PMID 9166705.
- Cannon JG, Angel JB, Abad LW, Vannier E, Mileno MD, Fagioli L, Wolff SM, Komaroff AL (May 1997). "Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome". Journal of Clinical Immunology. 17 (3): 253–61. doi:10.1023/A:1027314713231. PMID 9168406. S2CID 13013291.
- Fink GW, Norman JG (Dec 1997). "Specific changes in the pancreatic expression of the interleukin 1 family of genes during experimental acute pancreatitis". Cytokine. 9 (12): 1023–7. doi:10.1006/cyto.1997.0260. PMID 9417814.
External links
- IL1R2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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