Integrin alpha 6

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

ITGA6
Identifiers
AliasesITGA6, CD49f, ITGA6B, VLA-6, integrin subunit alpha 6, JEB6
External IDsOMIM: 147556 MGI: 96605 HomoloGene: 20091 GeneCards: ITGA6
Orthologs
SpeciesHumanMouse
Entrez

3655

16403

Ensembl

ENSG00000091409

ENSMUSG00000027111

UniProt

P23229

Q61739

RefSeq (mRNA)

NM_001277970
NM_008397

RefSeq (protein)

NP_000201
NP_001073286
NP_001303235
NP_001352458
NP_001352459

NP_001264899
NP_032423
NP_001393187

Location (UCSC)Chr 2: 172.43 – 172.51 MbChr 2: 71.58 – 71.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.[5] Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas.[6]

Interactions

ITGA6 has been shown to interact with TSPAN4[7] and GIPC1.[8]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000091409 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027111 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ITGA6 integrin, alpha 6".
  6. De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyère E, Lefebvre O, et al. (October 2017). "Hemidesmosome integrity protects the colon against colitis and colorectal cancer". Gut. 66 (10): 1748–1760. doi:10.1136/gutjnl-2015-310847. PMC 5595104. PMID 27371534.
  7. Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". The Journal of Biological Chemistry. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.
  8. Tani TT, Mercurio AM (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". The Journal of Biological Chemistry. 276 (39): 36535–42. doi:10.1074/jbc.M105785200. PMID 11479315.

Further reading

  • Lipscomb EA, Mercurio AM (September 2005). "Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression". Cancer and Metastasis Reviews. 24 (3): 413–23. doi:10.1007/s10555-005-5133-4. PMID 16258729. S2CID 26150860.


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