Integrin beta 5

Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.[5][6]

ITGB5
Identifiers
AliasesITGB5, Integrin, beta 5, integrin subunit beta 5
External IDsOMIM: 147561 MGI: 96614 HomoloGene: 20511 GeneCards: ITGB5
Orthologs
SpeciesHumanMouse
Entrez

3693

16419

Ensembl

ENSG00000082781

ENSMUSG00000022817

UniProt

P18084

O70309

RefSeq (mRNA)

NM_002213
NM_001354764
NM_001354765
NM_001354766

NM_001145884
NM_010580

RefSeq (protein)

NP_002204
NP_001341693
NP_001341694
NP_001341695

NP_001139356
NP_034710
NP_001391992

Location (UCSC)Chr 3: 124.76 – 124.9 MbChr 16: 33.65 – 33.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

Integrin, beta 5 has been shown to interact with PTK2,[7] Annexin A5[8] and PAK4.[9]

Functions

ITGB5 encodes a subunit of integrin that can interact with several alpha chains to form a variety of integrin heterodimers. It also plays a potential role in intercellular communication during tumor progression and metastasis.[10]

Clinical significance

Research

Elevated levels of ITGB5 have been found in patients with autosomal dominant osteopetrosis type II, a rare disease of bones.[11]

References

  1. GRCh38: Ensembl release 89: ENSG00000082781 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022817 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. McLean JW, Vestal DJ, Cheresh DA, Bodary SC (Nov 1990). "cDNA sequence of the human integrin beta 5 subunit". J Biol Chem. 265 (28): 17126–31. doi:10.1016/S0021-9258(17)44878-2. PMID 2211615.
  6. "Entrez Gene: ITGB5 integrin, beta 5".
  7. Eliceiri, Brian P; Puente Xose S; Hood John D; Stupack Dwayne G; Schlaepfer David D; Huang Xiaozhu Z; Sheppard Dean; Cheresh David A (Apr 2002). "Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". J. Cell Biol. 157 (1): 149–60. doi:10.1083/jcb.200109079. ISSN 0021-9525. PMC 2173263. PMID 11927607.
  8. Cardó-Vila, Marina; Arap Wadih; Pasqualini Renata (May 2003). "Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V". Mol. Cell. 11 (5): 1151–62. doi:10.1016/S1097-2765(03)00138-2. ISSN 1097-2765. PMID 12769841.
  9. Zhang, Hongquan; Li Zhilun; Viklund Eva-Karin; Strömblad Staffan (Sep 2002). "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration". J. Cell Biol. 158 (7): 1287–97. doi:10.1083/jcb.200207008. ISSN 0021-9525. PMC 2173231. PMID 12356872.
  10. Zhang, Lu-yang; Guo, Qing; Guan, Ge-fei; Cheng, Wen; Cheng, Peng; Wu, An-hua (2019). "Integrin Beta 5 Is a Prognostic Biomarker and Potential Therapeutic Target in Glioblastoma". Frontiers in Oncology. 9: 904. doi:10.3389/fonc.2019.00904. ISSN 2234-943X. PMC 6764112. PMID 31616629.
  11. Coudert, AE (Mar 2014). "Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology" (PDF). Lab. Invest. 94 (3): 275–285. doi:10.1038/labinvest.2013.140. PMID 24336069. S2CID 5097233.

Further reading


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