Interleukin-7 receptor-α

Interleukin-7 receptor subunit alpha (IL7R-α) also known as CD127 (Cluster of Differentiation 127) is a protein that in humans is encoded by the IL7R gene.[5][6]

IL7R
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL7R, CD127, CDW127, IL-7R-alpha, IL7RA, ILRA, Interleukin-7 receptor-α, interleukin 7 receptor
External IDsOMIM: 146661 MGI: 96562 HomoloGene: 1646 GeneCards: IL7R
Orthologs
SpeciesHumanMouse
Entrez

3575

16197

Ensembl

ENSG00000168685

ENSMUSG00000003882

UniProt

P16871

P16872

RefSeq (mRNA)

NM_002185

NM_008372
NM_001355680

RefSeq (protein)

NP_002176

NP_032398
NP_001342609

Location (UCSC)Chr 5: 35.85 – 35.88 MbChr 15: 9.51 – 9.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

IL7R-α is a type I cytokine receptor and is a subunit of the functional Interleukin-7 receptor and Thymic Stromal Lymphopoietin (TSLP) receptors.

References

  1. GRCh38: Ensembl release 89: ENSG00000168685 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000003882 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: IL7R interleukin 7 receptor".
  6. Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk BA, Gimpel S, Cosman D, Dower SK, March CJ, Namen AE (March 1990). "Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily". Cell. 60 (6): 941–51. doi:10.1016/0092-8674(90)90342-C. PMID 2317865. S2CID 45181020.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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