Cation channel superfamily

The transmembrane cation channel superfamily was defined in InterPro and Pfam as the family of tetrameric ion channels. These include the sodium, potassium,[1] calcium, ryanodine receptor, HCN, CNG, CatSper, and TRP channels. This large group of ion channels apparently includes families 1.A.1, 1.A.2, 1.A.3, and 1.A.4 of the TCDB transporter classification.

See also: Voltage-gated ion channel
Ion channel (eukaryotic)
Potassium channel Kv1.2 (with beta2 auxiliary subunits), structure in a membrane-like environment. Calculated hydrocarbon boundaries of the lipid bilayer are indicated by red and blue dots.
Identifiers
SymbolIon_trans
PfamPF00520
InterProIPR005821
SCOP21bl8 / SCOPe / SUPFAM
TCDB1.A.1
OPM superfamily8
OPM protein2a79
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1qg9A:157-176 2a79B:225-409 1ho7A:378-397 1ho2A:378-397 1ujlA:570-611
Ion channel (bacterial)
Potassium channel KcsA. Calculated hydrocarbon boundaries of the lipid bilayer are indicated by red and blue dots.
Identifiers
SymbolIon_trans_2
PfamPF07885
InterProIPR013099
SCOP21bl8 / SCOPe / SUPFAM
OPM protein1r3j
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1lnqE:25-100 2a0lB:169-250 1orqC:169-250

1k4cC:34-116 1r3iC:34-116 2bocC:34-116 1j95C:34-116 1r3lC:34-116 1jvmB:34-116 1bl8C:34-116 2a9hD:34-116 1k4dC:34-116 1r3jC:34-116 1r3kC:34-116 2bobC:34-116

1p7bB:77-151

They are described as minimally having two transmembrane helices flanking a loop which determines the ion selectivity of the channel pore. Many eukaryotic channels have four additional transmembrane helices (TM) (Pfam PF00520), related to or vestigial of voltage gating. The proteins with only two transmembrane helices (Pfam PF07885) are most commonly found in bacteria. This also includes the 2-TM inward-rectifier potassium channels (Pfam PF01007) found primarily in eukaryotes. There are commonly additional regulatory domains which serve to regulate ion conduction and channel gating. The pores may also be homotetramers or heterotetramers; where heterotetramers may be encoded as distinct genes or as multiple pore domains within a single polypeptide. The HVCN1 and Putative tyrosine-protein phosphatase proteins do not contain an expected ion conduction pore domain, but rather have homology only to the voltage sensor domain of voltage gated ion channels.

Human channels with 6 TM helices

Transient receptor potential
Main article: Transient receptor potential channel
Canonical
Main article: Canonical TRP channels
Melastatin
Main article: Melastatin TRP channels
Vanilloid
Main article: Vanilloid TRP channels
Mucolipin
Main article: Mucolipin TRP channels
Ankyrin
Main article: Ankyrin TRP channels
TRPP
Main article: Transient Receptor Potential Polycystic
  • PKD1L3;

Voltage-dependent
Main article: Voltage-dependent calcium channels

Sperm
Main article: Cation channels of sperm

Ryanodine receptor
Main article: Ryanodine receptor

Voltage-gated potassium
Main article: Voltage-gated potassium channels
Delayed rectifier
A-type potassium
  • Kvα1.x - Shaker-related: Kv1.4 (KCNA4)
  • Kvα3.x - Shaw-related: Kv3.3 (KCNC3), Kv3.4 (KCNC4)
  • Kvα4.x - Shal-related: Kv4.1 (KCND1), Kv4.2 (KCND2), Kv4.3 (KCND3)
Outward-rectifying
Inwardly-rectifying
Slowly activating
Modifier/silencer

Calcium-activated
Main article: Calcium-activated potassium channels
BK
Main article: BK channels
SK
Main article: SK channels
  • KCa2.x: KCa2.1 (KCNN1) - SK1, KCa2.2 (KCNN2) - SK2, KCa2.3 (KCNN3) - SK3
  • KCa3.x: KCa3.1 (KCNN4) - SK4
  • KCa4.x: KCa4.1 (KCNT1) - SLACK, KCa4.2 (KCNT2) - SLICK
IK
Main article: IK channels
Other subfamilies

Inward-rectifier potassium
Main article: Inward-rectifier potassium ion channel

Sodium

Cyclic nucleotide-gated

Proton

Human channels with 2 TM helices in each subunit

Tandem pore domain potassium channel
Main article: Tandem pore domain potassium channel

Non-human channels

Two-pore
Main article: Two-pore channels

Pore-only potassium
Main article: Pore-only potassium channels

Ligand-gated potassium

Voltage-gated potassium
Main article: Voltage-gated potassium channels

Prokaryotic KCa
Main article: Prokaryotic KCa channels

Voltage and cyclic nucleotide gated potassium

Sodium

Non-selective

Prokaryotic inward-rectifier potassium
Main article: Inward-rectifier potassium channels

Engineered

References
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This article incorporates text from the public domain Pfam and InterPro: IPR005821
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