ITPR1

Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene.[5][6][7][8][9]

ITPR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesITPR1, ACV, CLA4, INSP3R1, IP3R, IP3R1, PPP1R94, SCA15, SCA16, SCA29, inositol 1,4,5-trisphosphate receptor type 1
External IDsOMIM: 147265 MGI: 96623 HomoloGene: 1673 GeneCards: ITPR1
Orthologs
SpeciesHumanMouse
Entrez

3708

16438

Ensembl

ENSG00000150995

ENSMUSG00000030102

UniProt

Q14643

P11881

RefSeq (mRNA)

NM_001099952
NM_001168272
NM_002222
NM_001378452

NM_010585

RefSeq (protein)

NP_001093422
NP_001161744
NP_002213

NP_034715

Location (UCSC)Chr 3: 4.49 – 4.85 MbChr 6: 108.19 – 108.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

ITPR1 has been shown to interact with:

See also

References
  1. GRCh38: Ensembl release 89: ENSG00000150995 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030102 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yamada N, Makino Y, Clark RA, Pearson DW, Mattei MG, Guénet JL, Ohama E, Fujino I, Miyawaki A, Furuichi T (Sep 1994). "Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization". The Biochemical Journal. 302 (Pt 3): 781–90. doi:10.1042/bj3020781. PMC 1137299. PMID 7945203.
  6. Nucifora FC, Li SH, Danoff S, Ullrich A, Ross CA (Sep 1995). "Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant". Brain Research. Molecular Brain Research. 32 (2): 291–6. doi:10.1016/0169-328X(95)00089-B. PMID 7500840.
  7. van de Leemput J, Chandran J, Knight MA, Holtzclaw LA, Scholz S, Cookson MR, Houlden H, Gwinn-Hardy K, Fung HC, Lin X, Hernandez D, Simon-Sanchez J, Wood NW, Giunti P, Rafferty I, Hardy J, Storey E, Gardner RJ, Forrest SM, Fisher EM, Russell JT, Cai H, Singleton AB (Jun 2007). "Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans". PLOS Genetics. 3 (6): e108. doi:10.1371/journal.pgen.0030108. PMC 1892049. PMID 17590087.
  8. Iwaki A, Kawano Y, Miura S, Shibata H, Matsuse D, Li W, Furuya H, Ohyagi Y, Taniwaki T, Kira J, Fukumaki Y (Jan 2008). "Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 16". Journal of Medical Genetics. 45 (1): 32–5. doi:10.1136/jmg.2007.053942. PMID 17932120. S2CID 7730102.
  9. "Entrez Gene: ITPR1 inositol 1,4,5-triphosphate receptor, type 1".
  10. Ando H, Mizutani A, Matsu-ura T, Mikoshiba K (Mar 2003). "IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor". The Journal of Biological Chemistry. 278 (12): 10602–12. doi:10.1074/jbc.M210119200. PMID 12525476.
  11. Hirota J, Ando H, Hamada K, Mikoshiba K (Jun 2003). "Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1". The Biochemical Journal. 372 (Pt 2): 435–41. doi:10.1042/BJ20030110. PMC 1223404. PMID 12611586.
  12. Maximov A, Tang TS, Bezprozvanny I (Feb 2003). "Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons". Molecular and Cellular Neurosciences. 22 (2): 271–83. doi:10.1016/s1044-7431(02)00027-1. PMID 12676536. S2CID 2317354.
  13. MacMillan D, Currie S, Bradley KN, Muir TC, McCarron JG (Dec 2005). "In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin". Journal of Cell Science. 118 (Pt 23): 5443–51. doi:10.1242/jcs.02657. PMID 16278292.
  14. Cameron AM, Nucifora FC, Fung ET, Livingston DJ, Aldape RA, Ross CA, Snyder SH (Oct 1997). "FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain". The Journal of Biological Chemistry. 272 (44): 27582–8. doi:10.1074/jbc.272.44.27582. PMID 9346894.
  15. Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (Mar 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature. 404 (6774): 197–201. Bibcode:2000Natur.404..197S. doi:10.1038/35004606. PMID 10724174. S2CID 205004996.
  16. Mehta D, Ahmmed GU, Paria BC, Holinstat M, Voyno-Yasenetskaya T, Tiruppathi C, Minshall RD, Malik AB (Aug 2003). "RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability". The Journal of Biological Chemistry. 278 (35): 33492–500. doi:10.1074/jbc.M302401200. PMID 12766172.
  17. Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (Sep 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell. 114 (6): 777–89. doi:10.1016/s0092-8674(03)00716-5. PMID 14505576. S2CID 10552676.
  18. Mery L, Magnino F, Schmidt K, Krause KH, Dufour JF (Jan 2001). "Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors". FEBS Letters. 487 (3): 377–83. doi:10.1016/s0014-5793(00)02362-0. PMID 11163362. S2CID 44945442.
  19. Argent L, Winter F, Prickett L, Carrasquero-Ordaz M, Olsen AL, Kramer H, Lancaster E, Becker EB (Sep 2020). "Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulatesPurkinje cell morphology". The Journal of Biological Chemistry. 295 (36): 12716–26. doi:10.1074/jbc.RA120.012655. PMC 7476715. PMID 32675284.

Further reading
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