Jayant B. Udgaonkar

Results of protein folding.

Jayant Udgaonkar, born on 22 March 1960 in the Indian state of Maharashtra, did his graduate studies in chemistry at St. Xavier's College, Mumbai during 1976–79 and secured his master's degree from the Indian Institute of Technology, Chennai in 1981.[9] Moving to Cornell University, he completed his doctoral studies under the guidance of George P. Hess to obtain a PhD for his thesis on acetylcholine receptor in 1986 after which did his post-doctoral studies under Robert Lesh Baldwin at Stanford University during 1986–89.[10] Returning to India, he joined National Centre for Biological Sciences of Tata Institute of Fundamental Research as a reader in 1990 and has been serving as a professor since 2007. In between, he held the positions of an associate professor (1995–98), Dean (1997–2008), Head of Administration (1997–2008), Head of Research (1997–2008), Head of Technical Services (1998–2000) and a professor (1998–2007) at the institute and served as an honorary faculty member at the Jawaharlal Nehru Centre for Advanced Scientific Research in 1999.[9] On 1 November 2017, he became the second director of the Indian Institute of Science Education and Research, Pune, succeeding Prof. Krishna N. Ganesh and served the office till 2023.[11]

During his doctoral studies at Cornell University, Udgaonkar is known to have developed a protocol for rapid chemical kinetic studies at the cell surface.[10] Later, while pursuing his post-doctoral studies, he developed methodologies for hydrogen exchange using Nuclear magnetic resonance spectroscopy for exploring the intermediates populating protein folding pathways. Furthering his Stanford studies on protein folding at NCBS, he propounded the theory that initial hydrophobic collapse is the first stage in protein folding, which he demonstrated using a model protein barstar and elucidated the various transition stages of protein folding and unfolding.[12] He has also demonstrated that, contrary to the general understanding that a single dominant barrier slows down the protein folding, several distributed small barriers can also influence the reaction.[10] His current work focuses on formation of amyloid fibrils and his research has shown multiple pathways of aggregation in the formation of amyloid fibrils of different morphologies.[13]

Udgaonkar has published a number of articles in peer reviewed journals detailing his researches,[note 1] Google Scholar and ResearchGate, two online repositories of scientific articles, have listed several of them.[14][15] He was a former guest editor of the Current Opinion in Structural Biology of Elsevier (2013 and 2015) and a former editorial board member of Folding and Design (1996–98).

Udgaonkar, who stood first in the BSc chemistry examinations of the University of Mumbai in 1979, received several scholarships and research fellowships including the National Merit Scholarship of the Government of India, Merit Scholarship of the Indian Institute of Technology, Madras, Jane Coffin Childs Memorial Fund for Medical Research fellowship, Biotechnology Career Fellowship of Rockefeller Foundation, Golden Jubilee Biotechnology fellowship of the Department of Biotechnology, Swarnajayanti fellowship of the Department of Science and Technology and senior research fellowship of Wellcome Trust and is a J. C. Bose National Fellow of the Department of Science and Technology, the tenancy of the fellowship running from 2007 till 2017.[9] He received the Birla Award in Biology in 1996 and the Indian Academy of Sciences elected him as a fellow in 1997.[16] The Council of Scientific and Industrial Research awarded him the Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards, in 2000.[7] He became an elected fellow of the Indian National Science Academy in 2002 and The World Academy of Sciences elected him as a fellow in 2007.[6]

• Sabareesan Ambadi Thody, Jayant B Udgaonkar (August 2016). "Pathogenic Mutations within the Disordered Palindromic Region of the Prion Protein Induce Structure Therein and Accelerate the Formation of Misfolded Oligomers". Journal of Molecular Biology. 428 (20): 3935–3947. doi:10.1016/j.jmb.2016.08.015. PMID 27545411.
• Pooja Malhotra, Jayant B Udgaonkar (August 2016). "How cooperative are protein folding and unfolding transitions?: Cooperativity in protein folding/unfolding reactions". Protein Science. 25 (11): 1924–1941. doi:10.1002/pro.3015. PMC 5079258. PMID 27522064.
• Rama Reddy Goluguri, Jayant B Udgaonkar (June 2016). "Microsecond Rearrangements of Hydrophobic Clusters in an Initially Collapsed Globule Prime Structure Formation during the Folding of a Small Protein". Journal of Molecular Biology. 428 (15): 3102–3117. doi:10.1016/j.jmb.2016.06.015. PMID 27370109.
• Singh, Jogender; Kumar, Harish; Sabareesan, Ambadi T.; Udgaonkar, Jayant B. (3 December 2014). "Rational Stabilization of Helix 2 of the Prion Protein Prevents Its Misfolding and Oligomerization". Journal of the American Chemical Society. 136 (48): 16704–16707. doi:10.1021/ja510964t. ISSN 0002-7863. PMID 25407394.
• Zaidi, Faisal N.; Nath, Utpal; Udgaonkar, Jayant B. (December 1997). "Multiple intermediates and transition states during protein unfolding". Nature Structural Biology. 4 (12): 1016–1024. doi:10.1038/nsb1297-1016. ISSN 1072-8368. PMID 9406552. S2CID 1692527.
• Vishwas R Agashe, Jayant B Udgaonkar (March 1995). "Thermodynamics of denaturation of barstar: evidence for cold denaturation and evaluation of the interaction with guanidine hydrochloride". Biochemistry. 34 (10): 3286–99. doi:10.1021/bi00010a019. PMID 7880824.
• Ritu Khurana, Jayant B Udgaonkar (January 1994). "Equilibrium unfolding studies of barstar: evidence for an alternative conformation which resembles a molten globule". Biochemistry. 33 (1): 106–115. doi:10.1021/bi00167a014. PMID 8286327.
• Jayant B Udgaonkar, Robert L Baldwin (November 1990). "Early folding intermediate of ribonuclease A." Proceedings of the National Academy of Sciences. 87 (21): 8197–8201. Bibcode:1990PNAS...87.8197U. doi:10.1073/pnas.87.21.8197. PMC 54922. PMID 2236032.

• "Jayant Udgaonkar, Ph.D. on Chemistry Tree". Scientist profile. Chemistry Tree. 2016. Retrieved 16 October 2016.