Iodine (125I) human albumin

Iodine (125I) human albumin (trade name Jeanatope) is human serum albumin iodinated with iodine-125, typically injected to aid in the determination of total blood and plasma volume.[1][2]

Iodine (125I) human albumin
Clinical data
Trade namesJeanatope
AHFS/Drugs.comFDA Professional Drug Information
Routes of
administration		Intravenous injection
ATC code
Legal status
Legal status
Pharmacokinetic data
Elimination half-life~14 days
Excretionvia kidneys
Identifiers
PubChem SID
DrugBank
UNII
KEGG

Iodine-131 iodinated albumin (trade name Volumex) is used for the same purposes.[3]

Medical uses

Iodine (125I) human albumin is used to determine a person's blood volume. For this purpose, a defined amount of radioactivity in form of this drug is injected into a vein, and blood samples are drawn from a different body location after five and fifteen minutes. From the radioactivity of these samples, the original radioactivity per blood volume can be calculated; and knowing the total amount of radioactivity injected, one can calculate the total blood volume.[1]

It can also be used to calculate the blood plasma volume using a similar method. The main difference is that the drawn blood sample has to be centrifuged to separate the plasma from the blood cells.[1]

Contraindications

The US Food and Drug Administration lists no contraindications for this drug.[1]

Adverse effects

There is a theoretical possibility of allergic reactions after repeated use of this medication.[1]

Pharmacokinetics

Iodine-125 is a radioactive isotope of iodine that decays by electron capture with a physical half-life of 60.14 days. The biological half-life in normal individuals for iodine (125I) human albumin has been reported to be approximately 14 days. Its radioactivity is excreted almost exclusively via the kidneys.[1]

References
  1. Jeanatope FDA Professional Drug Information. Accessed 21 April 2021.
  2. DrugBank DB09429 . Accessed 21 April 2021.
  3. Volumex Injection FDA Professional Drug Information. Accessed 21 April 2021.
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