Mexican Federal Highway 180D

Highway 180D begins south of Campeche City, absorbing the local road Maestros Campechanos and immediately intersecting the Campeche Beltway (Periférico Pablo García y Montilla) with a full cloverleaf. Proceeding southwest, the next interchange is at Seybaplaya and is immediately followed by a toll plaza booth, the only one on the road.[6] The road ends south of Villa Madero, and traffic proceeds down Highway 180 to Champotón.

In 2015, one lane of a toll plaza booth was rendered inoperable after a trailer's brakes failed.[13]

Highway 180D begins east of Mérida, at Kantunil, splitting off from its non-toll counterpart, Federal Highway 180. Almost immediately, it has an interchange at the southern end of Yucatán State Route 53, connecting to Izamal, and an option to merge back onto Highway 180 toward Holca.[16] It proceeds east-southeast through rural Yucatán, with a toll plaza booth north of Pisté. It bypasses Valladolid, with access to the town provided by a full cloverleaf interchange with Highway 295. To the west is an oasis with a Pemex gas station and restaurants. It then edges to the east-northeast, roughly paralleling Highway 180 for the rest of its length.

Highway 180D crosses into Quintana Roo north of Nuevo X-can in Lázaro Cárdenas Municipality. East of here is its interchange with Highway 305D and its toll extension, connecting to Quintana Roo State Route 5 to the north and Playa del Carmen to the southeast. A toll plaza booth is located immediately east of the Highway 305D interchange. After the spur to Playa del Carmen, the road parallels Highway 180 until its merges with other roads. Travelers heading eastbound have the option to merge with non-toll Highway 180, which becomes Avenida López Portillo in Cancún, or to make a right turn and follow Quintana Roo State Route 180 toward Highway 307 with access to the Cancún International Airport.[16]

The Autopista Mérida-Cancún was formally opened on December 23, 1991, by President Carlos Salinas de Gortari.[14] Operation of the road was a joint venture between Fomento de Infraestructura Turística, S.A. de C.V. (Fomintur) and Consorcio del Mayab. In 2011, Fomintur was declared behind on its payments, resulting in its dissolution. Ultimately, ICA was awarded the contract to operate the road.

A provision in its concession allowed it to build a spur to Playa del Carmen,[17] and in 2014, this spur, legally considered part of Highway 180D[1] but signaged as Highway 305D (El Tintal-Playa del Carmen), opened, shortening travel times between the state of Yucatán and Playa del Carmen. As a result of the opening of the new road, the toll plaza was relocated 21 kilometers.[14]

In 2013, 200 teachers took over one of the highway's toll plaza booths, refusing to charge passing vehicles.[15]

In February 2017, Consorcio del Mayab raised tolls on the road. Vehicles are now charged a toll of 165 pesos between Mérida and Valladolid and 285 pesos between Valladolid and Cancún.[15] Even prior to the toll increases, the highway was the second most expensive toll road in Mexico.[14]