Microsomal triglyceride transfer protein

MTTP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	6I7S, 8EOJ
Identifiers
Aliases	MTTP, ABL, MTP, Microsomal triglyceride transfer protein
External IDs	OMIM: 157147 MGI: 106926 HomoloGene: 212 GeneCards: MTTP
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	99,623,997 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	137,850,729 bp[2]
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; liver; ; duodenum; ; right lobe of liver; ; kidney tubule; ; kidney; ; testicle; ; ganglionic eminence; ; metanephric glomerulus; ; gallbladder;
	Top expressed in
	jejunum; ; duodenum; ; left lobe of liver; ; ileum; ; yolk sac; ; spermatocyte; ; Intestinal epithelium; ; crypt of lieberkuhn of small intestine; ; spermatid; ; sexually immature organism;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein heterodimerization activity; protein binding; phospholipid transporter activity; lipid binding; lipid transporter activity;
Cellular component	receptor complex; endoplasmic reticulum lumen; endoplasmic reticulum; Golgi apparatus; basolateral plasma membrane;
Biological process	phospholipid transport; lipid transport; plasma lipoprotein particle assembly; lipid metabolism; protein secretion; triglyceride transport; chylomicron assembly; very-low-density lipoprotein particle assembly; lipoprotein metabolic process; cholesterol homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	4547
	17777
	ENSG00000138823
	ENSMUSG00000028158
	P55157
	O08601
	NM_001300785; NM_000253; NM_001386140
	NM_001163457; NM_008642; NM_001355051; NM_001355052
	NP_000244; NP_001287714
	NP_001156929; NP_032668; NP_001341980; NP_001341981
	Wikidata
View/Edit Human	View/Edit Mouse

Microsomal triglyceride transfer protein large subunit is a protein that in humans is encoded by the MTTP gene.[5][6]

MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triaglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.[6]

Apolipoprotein B48 on chylomicra and Apolipoprotein B100 on LDL, IDL, and VLDL are important for MTP binding.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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|alt=Statin Pathway edit]]

Statin Pathway edit

The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

Pharmacology

Drugs that inhibit MTTP prevent the assembly of apo B-containing lipoproteins thus inhibiting the synthesis of chylomicrons and VLDL and leading to decrease in plasma levels of LDL-C.

Lomitapide (Juxtapid) was approved by the US FDA for adjunctive treatment of homozygous familial hypercholesterolemia.
Dirlotapide (Slentrol) and mitratapide (Yarvitan) are veterinary drugs for the management of obesity in dogs.

References

GRCh38: Ensembl release 89: ENSG00000138823 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028158 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Shoulders CC, Brett DJ, Bayliss JD, Narcisi TM, Jarmuz A, Grantham TT, Leoni PR, Bhattacharya S, Pease RJ, Cullen PM, et al. (Mar 1994). "Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein". Hum Mol Genet. 2 (12): 2109–16. doi:10.1093/hmg/2.12.2109. PMID 8111381.
"Entrez Gene: MTTP microsomal triglyceride transfer protein".

Luz JM, Lennarz WJ (1996). "Protein disulfide isomerase: A multifunctional protein of the endoplasmic reticulum". Stress-Inducible Cellular Responses. pp. 97–117. doi:10.1007/978-3-0348-9088-5_7. ISBN 978-3-0348-9901-7. PMID 8856971. {{cite book}}: |journal= ignored (help)
Wetterau JR, Lin MC, Jamil H (1997). "Microsomal triaglyceride transfer protein". Biochim. Biophys. Acta. 1345 (2): 136–50. doi:10.1016/s0005-2760(96)00168-3. PMID 9106493.
Gordon DA (1997). "Recent advances in elucidating the role of the microsomal triaglyceride transfer protein in apolipoprotein B lipoprotein assembly". Curr. Opin. Lipidol. 8 (3): 131–7. doi:10.1097/00041433-199706000-00002. PMID 9211060.
Ye J (2007). "Reliance of Host Cholesterol Metabolic Pathways for the Life Cycle of Hepatitis C Virus". PLOS Pathog. 3 (8): e108. doi:10.1371/journal.ppat.0030108. PMC 1959368. PMID 17784784.
Wetterau JR, Aggerbeck LP, Bouma ME, et al. (1992). "Absence of microsomal triaglyceride transfer protein in individuals with abetalipoproteinemia". Science. 258 (5084): 999–1001. Bibcode:1992Sci...258..999W. doi:10.1126/science.1439810. PMID 1439810.
Sharp D, Ricci B, Kienzle B, et al. (1994). "Human microsomal triaglyceride transfer protein large subunit gene structure". Biochemistry. 33 (31): 9057–61. doi:10.1021/bi00197a005. PMID 7545943.
Shoulders CC, Narcisi TM, Read J, et al. (1995). "The abetalipoproteinemia gene is a member of the vitellogenin family and encodes an alpha-helical domain". Nat. Struct. Biol. 1 (5): 285–6. doi:10.1038/nsb0594-285. PMID 7664034. S2CID 11860468.
Hagan DL, Kienzle B, Jamil H, Hariharan N (1994). "Transcriptional regulation of human and hamster microsomal triaglyceride transfer protein genes. Cell type-specific expression and response to metabolic regulators". J. Biol. Chem. 269 (46): 28737–44. doi:10.1016/S0021-9258(19)61967-8. PMID 7961826.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Sharp D, Blinderman L, Combs KA, et al. (1993). "Cloning and gene defects in microsomal triaglyceride transfer protein associated with abetalipoproteinaemia". Nature. 365 (6441): 65–9. Bibcode:1993Natur.365...65S. doi:10.1038/365065a0. PMID 8361539. S2CID 4334532.
Narcisi TM, Shoulders CC, Chester SA, et al. (1996). "Mutations of the Microsomal Triglyceride-Transfer–Protein Gene in Abetalipoproteinemia". Am. J. Hum. Genet. 57 (6): 1298–310. PMC 1801399. PMID 8533758.
Rehberg EF, Samson-Bouma ME, Kienzle B, et al. (1997). "A novel abetalipoproteinemia genotype. Identification of a missense mutation in the 97-kDa subunit of the microsomal triaglyceride transfer protein that prevents complex formation with protein disulfide isomerase". J. Biol. Chem. 271 (47): 29945–52. doi:10.1074/jbc.271.47.29945. PMID 8939939.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Linnik KM, Herscovitz H (1998). "Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state". J. Biol. Chem. 273 (33): 21368–73. doi:10.1074/jbc.273.33.21368. PMID 9694898.
Bradbury P, Mann CJ, Köchl S, et al. (1999). "A common binding site on the microsomal triaglyceride transfer protein for apolipoprotein B and protein disulfide isomerase". J. Biol. Chem. 274 (5): 3159–64. doi:10.1074/jbc.274.5.3159. PMID 9915855.
Wang J, Hegele RA (2000). "Microsomal triaglyceride transfer protein (MTP) gene mutations in Canadian subjects with abetalipoproteinemia". Hum. Mutat. 15 (3): 294–5. doi:10.1002/(SICI)1098-1004(200003)15:3<294::AID-HUMU14>3.0.CO;2-E. PMID 10679949.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[WikiPathways-7] The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138823 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028158 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8111381-5] Shoulders CC, Brett DJ, Bayliss JD, Narcisi TM, Jarmuz A, Grantham TT, Leoni PR, Bhattacharya S, Pease RJ, Cullen PM, et al. (Mar 1994). "Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein". Hum Mol Genet. 2 (12): 2109–16. doi:10.1093/hmg/2.12.2109. PMID 8111381.

[entrez-6] "Entrez Gene: MTTP microsomal triglyceride transfer protein".

Lipids: lipoprotein particle metabolism
Lipoprotein particle classes and subclasses	delivery of TGs: Chylomicron VLDL delivery of C and CE: IDL LDL lb LDL sd LDL Lp(a) HDL Remnant cholesterol
Apolipoproteins	APOA 1 2 4 5 APOB APOC 1 2 3 4 APOD APOE APOH SAA SAA1
Extracellular enzymes	LCAT LIPC LPL
Lipid transfer proteins	CETP MTTP PLTP
Cell surface receptors	HDL: SCARB1 IDL: LRP LRP1 LRP1B LRP2 LRP3 LRP4 LRP5 LRP5L LRP6 LRP8 LRP10 LRP11 LRP12 LDL: LDLR LRPAP1
ATP-binding cassette transporter	ABCA1 ABCG5 ABCG8

Microsomal triglyceride transfer protein

Interactive pathway map

Pharmacology

References

Further reading