N-acetylgalactosamine-4-sulfatase
N-acetylgalactosamine-4-sulfatase (EC 3.1.6.12, chondroitinsulfatase, chondroitinase, arylsulfatase B, acetylgalactosamine 4-sulfatase, N-acetylgalactosamine 4-sulfate sulfohydrolase) is an enzyme with systematic name N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase.[1][2][3] It catalyses the following reaction:
- Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.
| N-acetylgalactosamine-4-sulfatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.6.12 | ||||||||
| CAS no. | 55354-43-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
It also acts on N-acetylglucosamine 4-sulfate.
See also
References
- Farooqui AA (October 1976). "The desulphation of hexosamine sulphates by arylsulphatase B". Experientia. 32 (10): 1242–4. doi:10.1007/BF01953071. PMID 976430. S2CID 26640171.
- Gorham SD, Cantz M (December 1978). "Arylsulphatase B, an exo-sulphatase for chondroitin 4-sulphate tetrasaccharide". Hoppe-Seyler's Zeitschrift für Physiologische Chemie. 359 (12): 1811–4. doi:10.1515/bchm2.1978.359.2.1811. PMID 738706.
- Tsuji M, Nakanishi Y, Habuchi H, Ishihara K, Suzuki S (April 1980). "The common identity of UDP-N-acetylgalactosamine 4-sulfatase, nitrocatechol sulfatase (arylsulfatase), and chondroitin 4-sulfatase". Biochimica et Biophysica Acta. 612 (2): 373–83. doi:10.1016/0005-2744(80)90120-5. PMID 7370276.
External links
- N-acetylgalactosamine-4-sulfatase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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