Neuromedin N

Neuromedin N is a neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effects.[2][3][4][5][6][7] Composed of the amino acid sequence Lys-Ile-Pro-Tyr-Ile-Leu, neuromedin N is homologous to neurotensin, both of whose sequences are found on the pro neurotensin/neuromedin N precursor C-terminus.[8][9] Both sequences of neuromedin N as well as neurotensin are flanked by Lys-Arg amino acids, which comprise a consensus sequence for the endoprotease proprotein convertase.[8] Neuromedin N is primarily synthesized in the neural and intestinal tissues of mammals; in studies performed in mice, neuromedin N's physiological effects were shown to include hypothermia and analgesia, arising from the peptide's ligand association to and interaction with neurotensin type 2 (NTS2) G protein-coupled receptors.[8][10]

Neuromedin N[1]
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C38H63N7O8/c1-7-23(5)31(36(50)42-29(38(52)53)20-22(3)4)43-34(48)28(21-25-14-16-26(46)17-15-25)41-35(49)30-13-11-19-45(30)37(51)32(24(6)8-2)44-33(47)27(40)12-9-10-18-39/h14-17,22-24,27-32,46H,7-13,18-21,39-40H2,1-6H3,(H,41,49)(H,42,50)(H,43,48)(H,44,47)(H,52,53)/t23-,24-,27-,28-,29-,30-,31-,32-/m0/s1
    Key: RZMLVIHXZGQADB-YLUGYNJDSA-N
  • OC([C@H](CC(C)C)NC([C@@]([C@H](CC)C)([H])NC([C@H](CC1=CC=C(O)C=C1)NC([C@@H]2CCCN2C([C@](NC([C@@H](N)CCCCN)=O)([H])[C@H](CC)C)=O)=O)=O)=O)=O
Properties
C38H63N7O8
Molar mass 745.949
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Neuromedin N
Identifiers
SymbolNN
NCBI gene4922
HGNC8038
Other data
LocusChr. 12 q21

References
  1. "Neuromedin N - Compound Summary". PubChem. U.S. National Library of Medicine.
  2. Carraway RE, Mitra SP, Spaulding G (1992). "Posttranslational processing of the neurotensin/neuromedin-N precursor". Annals of the New York Academy of Sciences. 668 (1 The Neurobiol): 1–16. Bibcode:1992NYASA.668....1C. doi:10.1111/j.1749-6632.1992.tb27335.x. PMID 1463268. S2CID 43676778.
  3. Kitabgi P, De Nadai F, Rovère C, Bidard JN (1992). "Biosynthesis, maturation, release, and degradation of neurotensin and neuromedin N". Annals of the New York Academy of Sciences. 668 (1 The Neurobiol): 30–42. Bibcode:1992NYASA.668...30K. doi:10.1111/j.1749-6632.1992.tb27337.x. PMID 1463273. S2CID 34235211.
  4. Vincent JP (October 1995). "Neurotensin receptors: binding properties, transduction pathways, and structure". Cellular and Molecular Neurobiology. 15 (5): 501–512. doi:10.1007/BF02071313. PMID 8719037. S2CID 13335185.
  5. Adams DH, Hanson GR, Keefe KA (2001). "Differential effects of cocaine and methamphetamine on neurotensin/neuromedin N and preprotachykinin messenger RNA expression in unique regions of the striatum". Neuroscience. 102 (4): 843–851. doi:10.1016/S0306-4522(00)00530-3. PMID 11182247. S2CID 9152831.
  6. Friry C, Feliciangeli S, Richard F, Kitabgi P, Rovere C (February 2002). "Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and biological activity". Biochemical and Biophysical Research Communications. 290 (4): 1161–1168. doi:10.1006/bbrc.2001.6308. PMID 11811984.
  7. Kitabgi P (October 2006). "Differential processing of pro-neurotensin/neuromedin N and relationship to pro-hormone convertases". Peptides. 27 (10): 2508–2514. doi:10.1016/j.peptides.2006.03.038. PMID 16904237. S2CID 25645145.
  8. Tóth F, Mallareddy JR, Tourwé D, Lipkowski AW, Bujalska-Zadrozny M, Benyhe S, et al. (June 2016). "Synthesis and binding characteristics of [(3)H]neuromedin N, a NTS2 receptor ligand". Neuropeptides. 57: 15–20. doi:10.1016/j.npep.2015.12.004. PMID 26707235. S2CID 28725225.
  9. Minamino N, Kangawa K, Matsuo H (July 1984). "Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord". Biochemical and Biophysical Research Communications. 122 (2): 542–549. doi:10.1016/s0006-291x(84)80067-4. PMID 6547840.
  10. Dubuc I, Nouel D, Coquerel A, Menard JF, Kitabgi P, Costentin J (June 1988). "Hypothermic effect of neuromedin N in mice and its potentiation by peptidase inhibitors". European Journal of Pharmacology. 151 (1): 117–121. doi:10.1016/0014-2999(88)90699-1. PMID 3416919.
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