PLCB3

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an enzyme that in humans is encoded by the PLCB3 gene.[5][6]

PLCB3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPLCB3, phospholipase C beta 3, SMDCD
External IDsOMIM: 600230 MGI: 104778 HomoloGene: 47960 GeneCards: PLCB3
Orthologs
SpeciesHumanMouse
Entrez

5331

18797

Ensembl

ENSG00000149782

ENSMUSG00000024960

UniProt

Q01970

P51432

RefSeq (mRNA)

NM_000932
NM_001184883
NM_001316314

NM_001290349
NM_008874

RefSeq (protein)

NP_000923
NP_001171812
NP_001303243

NP_001277278
NP_032900

Location (UCSC)Chr 11: 64.25 – 64.27 MbChr 19: 6.93 – 6.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The gene codes for the enzyme phospholipase C β3. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.

Interactions

PLCB3 has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000149782 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024960 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Weber G, Friedman E, Grimmond S, Hayward NK, Phelan C, Skogseid B, Gobl A, Zedenius J, Sandelin K, Teh BT (March 1995). "The phospholipase C beta 3 gene located in the MEN1 region shows loss of expression in endocrine tumours". Hum. Mol. Genet. 3 (10): 1775–81. doi:10.1093/hmg/3.10.1775. PMID 7849701.
  6. "Entrez Gene: PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)".
  7. Hwang JI, Heo K, Shin KJ, Kim E, Yun C, Ryu SH, Shin HS, Suh PG (June 2000). "Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2". J. Biol. Chem. 275 (22): 16632–7. doi:10.1074/jbc.M001410200. PMID 10748023.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.